Verheyden Matthew J, Bilgic Asli, Murrell Dédée F
School of Medicine, University of Notre Dame, Sydney, Australia.
Acta Derm Venereol. 2020 Aug 17;100(15):adv00224. doi: 10.2340/00015555-3457.
Bullous pemphigoid is an autoimmune subepithelial disease characterised by pruritus followed by urticarial plaques and finally bullae on the skin and mucosa. Drug-associated bullous pemphigoid (DABP) is a term used to describe instances of bullous pemphigoid demonstrating clinical, histological, or immunopathological features identical or similar to those of the idiopathic form of bullous pemphigoid, associated with the systemic ingestion, or topical application of particular drugs. In this study, we conducted a comprehensive search of the literature according to PRISMA guidelines and a total of 170 publications were included in the final qualitative analysis. In conclusion, 89 drugs were implicated in DABP. The strongest evidence for DABP is seen with gliptins, PD-1/PD-L1 inhibitors, loop diuretics, penicillin and derivatives. An appreciation of the medications associated with bullous pemphigoid enables clinicians to identify potential cases of DABP earlier and cease the offending medication.
大疱性类天疱疮是一种自身免疫性上皮下疾病，其特征为瘙痒，随后出现风团性斑块，最终在皮肤和黏膜上形成水疱。药物相关性大疱性类天疱疮（DABP）是一个术语，用于描述大疱性类天疱疮的病例，这些病例表现出与特发性大疱性类天疱疮相同或相似的临床、组织学或免疫病理学特征，与特定药物的全身摄入或局部应用有关。在本研究中，我们根据PRISMA指南对文献进行了全面检索，最终定性分析纳入了170篇出版物。总之，有89种药物与DABP有关。与DABP相关证据最充分的药物是格列汀类、PD-1/PD-L1抑制剂、襻利尿剂、青霉素及其衍生物。了解与大疱性类天疱疮相关的药物可使临床医生更早地识别潜在的DABP病例，并停用引起问题的药物。
