多形红斑与HLA - Aw33和DRw53相关。

Erythema multiforme is associated to HLA-Aw33 and DRw53.

作者信息

Lepage V, Douay C, Mallet C, Binet O, Lemarchand F, Wallach D, Masset M, Colombani J, Degos L

机构信息

Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint Louis, France.

出版信息

Tissue Antigens. 1988 Sep;32(3):170-5. doi: 10.1111/j.1399-0039.1988.tb01654.x.

DOI:10.1111/j.1399-0039.1988.tb01654.x

PMID:3217933

Abstract

Erythema multiforme is an acute eruption of the skin and mucous membranes of various aetiologies. Forty-one unrelated patients were HLA typed for 53 specificities of the HLA-A, B, C, DR and DQ series. Frequencies of Aw33 and DRw53 were significantly increased: Aw33, 17.0% in patients vs 2.8% in controls (corrected p = 0.01, relative risk = 7.2); DRw53, 70.7% in patients vs 30.5% in controls (corrected p = 0.0005, relative risk = 5.5).

摘要

多形红斑是一种由多种病因引起的皮肤和黏膜急性发疹性疾病。对41例无亲缘关系的患者进行了HLA - A、B、C、DR和DQ系列53种特异性分型。Aw33和DRw53的频率显著升高：Aw33，患者中为17.0%，对照组中为2.8%（校正p = 0.01，相对风险 = 7.2）；DRw53，患者中为70.7%，对照组中为30.5%（校正p = 0.0005，相对风险 = 5.5）。