Zhou Yang, Zhang Ying, Han Jinming, Yang Mengge, Zhu Jie, Jin Tao
Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
J Transl Med. 2020 Mar 17;18(1):131. doi: 10.1186/s12967-020-02289-w.
Transitional B cells (TrB cells) represent a crucial link between immature B cells in the bone marrow and mature peripheral B cells. Although TrB cells represent one of the regulatory B cell subpopulations in healthy individuals, the frequency of CD24CD38 TrB cells in circulation may be altered in individuals with autoimmune diseases, such as multiple sclerosis, neuromyelitisoptica spectrum disorders, systemic lupus erythematosus, Sjögren's syndrome, rheumatoid arthritis, systemic sclerosis, and juvenile dermatomyositis. Although TrB cells play regulatory roles under inflammatory conditions, consequences of their functional impairment vary across autoimmune diseases. Since the origin, development, and function of TrB cells, especially in humans, remain unclear and controversial, this review aimed to discuss the characteristics of TrB cells at steady state and explore their role in various immune diseases, including autoimmune rheumatic diseases and neuroimmunological diseases.
过渡性B细胞（TrB细胞）是骨髓中未成熟B细胞与成熟外周B细胞之间的关键纽带。尽管TrB细胞是健康个体中调节性B细胞亚群之一，但在患有自身免疫性疾病（如多发性硬化症、视神经脊髓炎谱系障碍、系统性红斑狼疮、干燥综合征、类风湿关节炎、系统性硬化症和青少年皮肌炎）的个体中，循环中CD24CD38 TrB细胞的频率可能会发生改变。虽然TrB细胞在炎症条件下起调节作用，但其功能受损的后果在不同自身免疫性疾病中有所不同。由于TrB细胞的起源、发育和功能，尤其是在人类中，仍不清楚且存在争议，本综述旨在讨论稳态下TrB细胞的特征，并探讨它们在各种免疫疾病中的作用，包括自身免疫性风湿性疾病和神经免疫性疾病。
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