MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L87TX, UK.
MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA), Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, L87TX, UK.
Redox Biol. 2020 Aug;35:101484. doi: 10.1016/j.redox.2020.101484. Epub 2020 Feb 29.
Hydrogen peroxide appears to be the key reactive oxygen species involved in redox signalling, but comparisons of the low concentrations of hydrogen peroxide that are calculated to exist within cells with those previously shown to activate common signalling events in vitro indicate that direct oxidation of key thiol groups on "redox-sensitive" signalling proteins is unlikely to occur. A number of potential mechanisms have been proposed to explain how cells overcome this block to hydrogen peroxide-stimulated redox signalling and these will be discussed in the context of the redox-stimulation of specific adaptations of skeletal muscle to contractile activity and exercise. It is argued that current data implicate a role for currently unidentified effector molecules (likely to be highly reactive peroxidases) in propagation of the redox signal from sites of hydrogen peroxide generation to common adaptive signalling pathways.
过氧化氢似乎是参与氧化还原信号转导的关键活性氧物种，但将细胞内计算出的低浓度过氧化氢与先前在体外激活常见信号事件的浓度进行比较表明，直接氧化“氧化还原敏感”信号蛋白上的关键巯基不太可能发生。已经提出了许多潜在的机制来解释细胞如何克服这种阻止过氧化氢刺激的氧化还原信号转导的障碍，这些机制将在讨论骨骼肌对收缩活动和运动的特定适应的氧化还原刺激时进行讨论。有人认为，目前的数据表明，目前尚未鉴定的效应分子（可能是高反应性过氧化物酶）在从过氧化氢产生部位到常见适应性信号通路传播氧化还原信号中起作用。
