1Department of Inorganic Chemistry, Medical University of Gdansk, Gdansk, Poland.
2Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, USA.
Cell Mol Biol Lett. 2020 Mar 13;25:18. doi: 10.1186/s11658-020-00212-1. eCollection 2020.
During hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR). While their induced signaling pathways have many distinct targets, there are some important connections as well. Despite the extensive studies on both of these signaling pathways, the exact mechanisms involved that determine survival versus apoptosis remain largely unexplained and therefore beyond therapeutic control. Here we discuss the complex relationship between the HIF and UPR signaling pathways and the importance of understanding how these pathways differ between normal and cancer cell models.
在缺氧条件下，细胞会经历关键的适应性反应，包括缺氧诱导蛋白 (HIFs) 的上调和未折叠蛋白反应 (UPR) 的诱导。虽然它们的诱导信号通路有许多不同的靶点，但也有一些重要的联系。尽管对这两种信号通路都进行了广泛的研究，但决定细胞存活或凋亡的确切机制在很大程度上仍未得到解释，因此无法进行治疗控制。在这里，我们讨论了 HIF 和 UPR 信号通路之间的复杂关系，以及了解这些通路在正常细胞和癌细胞模型之间的差异的重要性。
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