Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA.
Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA.
Neuron. 2020 Mar 18;105(6):954-956. doi: 10.1016/j.neuron.2020.02.031.
In this issue of Neuron, Corkrum et al. (2020) demonstrate an unexpected role for dopamine D receptors on astrocytes located in the nucleus accumbens, a key structure of the brain's reward system. Activation of these receptors mediates dopamine-evoked depression of excitatory synaptic transmission, which contributes to amphetamine's psychomotor effects.
在本期《神经元》杂志中,Corkrum 等人(2020 年)证明了位于伏隔核中的星形胶质细胞上的多巴胺 D 受体的一个意想不到的作用,伏隔核是大脑奖励系统的一个关键结构。这些受体的激活介导了多巴胺引发的兴奋性突触传递的抑制,这有助于安非他命的精神运动效应。