Machado Isidro, Martínez Ciarpaglini Carolina, Nieto Morales Gema, Mata Daniel, Alfonso Ballester Raquel, Muñoz Sornosa Ernesto, Ferrandez Antonio
Departamento de Patología, Instituto Valenciano de Oncología, Valencia, España.
Fundación de Investigación del Hospital Clínico de Valencia (INCLIVA), Valencia, España.
Rev Esp Patol. 2020 Apr-Jun;53(2):121-125. doi: 10.1016/j.patol.2018.07.003. Epub 2018 Sep 3.
Extraovarian granulosa cell tumor is a very uncommon tumor and the identification of a recurrent mutation in FOXL2 may be used as another diagnostic tool along with the classical morphological and immunohistochemical findings. Here, we report a new case of extraovarian granulosa cell tumor in a 57 years old female patient presented with a sub-hepatic mass and abdominal pain. Histopathological examination of the excised mass showed features of adult-type granulosa cell tumor with α-inhibin, calretinin, WT1, S100, CD99 and progesterone receptor immunoreactivity. A FOXL2 mutation was detected on molecular biology study. A final diagnosis was an extraovarian adult-type granulosa cell tumor. We discuss the histopathological and immunohistochemical differential diagnosis.
卵巢外颗粒细胞瘤是一种非常罕见的肿瘤，FOXL2基因复发性突变的鉴定可作为一种辅助诊断工具，与经典的形态学和免疫组化结果一同使用。在此，我们报告一例57岁女性患者的卵巢外颗粒细胞瘤新病例，该患者表现为肝下肿块和腹痛。对切除肿块的组织病理学检查显示为成年型颗粒细胞瘤特征，α-抑制素、钙视网膜蛋白、WT1、S100、CD99和孕激素受体呈免疫反应性。分子生物学研究检测到FOXL2突变。最终诊断为卵巢外成年型颗粒细胞瘤。我们讨论了组织病理学和免疫组化鉴别诊断。
