并非所有 HLA 表位错配都一样。
Not all HLA epitope mismatches are equal.
机构信息
Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands.
Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands.
出版信息
Kidney Int. 2020 Apr;97(4):653-655. doi: 10.1016/j.kint.2019.12.017.
The future of HLA matching in solid organ transplantation lies in epitope matching. The article by Sapir-Pichhadze et al. provides indirect evidence that there is a difference in immunogenicity between antibody-verified versus non-verified eplets. However, this difference was less clear for HLA class II, showing the need for additional efforts to identify truly immunogenic HLA class II epitope mismatches.
实体器官移植中 HLA 配型的未来在于表位配型。Sapir-Pichhadze 等人的文章提供了间接证据，表明抗体验证与非验证表位之间存在免疫原性差异。然而，对于 HLA Ⅱ类，这种差异不太明显，这表明需要进一步努力来确定真正具有免疫原性的 HLA Ⅱ类表位错配。
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