脑内组成型雄烷受体和孕烷 X 受体。
The constitutive androstane receptor and pregnane X receptor in the brain.
机构信息
Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
Centro de Microscopía Avanzada, CMA-BIO BIO, Laboratorio de Neurobiología y Células Madres NeuroCellT, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
出版信息
Br J Pharmacol. 2020 Jun;177(12):2666-2682. doi: 10.1111/bph.15055. Epub 2020 Apr 22.
Abstract
Since their discovery, the orphan nuclear receptors constitutive androstane receptor (CAR;NR1I3) and pregnane X receptor (PXR;NR1I2) have been regarded as master regulators of drug disposition and detoxification mechanisms. They regulate the metabolism and transport of endogenous mediators and xenobiotics in organs including the liver, intestine and brain. However, with proposals of new physiological functions for NR1I3 and NR1I2, there is increasing interest in the role of these receptors in influencing brain function. This review will summarise key findings regarding the expression and function of NR1I3 and NR1I2 in the brain, hereby highlighting the need for further research in this field.
摘要
自发现以来，孤儿核受体组成型雄烷受体（CAR；NR1I3）和孕烷 X 受体（PXR；NR1I2）一直被视为药物处置和解毒机制的主要调节因子。它们调节包括肝脏、肠道和大脑在内的器官中外源物质和内源性介质的代谢和转运。然而，随着对 NR1I3 和 NR1I2 新的生理功能的提出，人们对这些受体在影响大脑功能方面的作用越来越感兴趣。本综述将总结 NR1I3 和 NR1I2 在大脑中的表达和功能的关键发现，强调该领域进一步研究的必要性。
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