Kobrinski Daniel A, Yang Haining, Kittaneh Muaiad
Department of Oncology, Loyola University Chicago, Maywood, IL, USA.
Department of Cancer Biology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Transl Lung Cancer Res. 2020 Feb;9(Suppl 1):S60-S66. doi: 10.21037/tlcr.2019.11.24.
BRCA-1 associated protein 1 () is a tumor suppressor gene that has been implicated in the pathogenesis of several malignancies and is gaining more recognition as a crucial gene that could be amenable to therapeutic manipulation. There is a growing interest in prevention and establishing cancer screening guidelines in patients with germline mutations to aid with early detection and treatment of associated malignancies. We aim to give a concise review of and its role in carcinogenesis, the cancer predisposition syndrome and discuss clinical implications including suggested screening guidelines, and potential targeted therapeutic options.
BRCA-1相关蛋白1（）是一种肿瘤抑制基因，已被认为与多种恶性肿瘤的发病机制有关，并且作为一种可能适合进行治疗性调控的关键基因而受到越来越多的关注。对于携带种系突变的患者，预防和制定癌症筛查指南以帮助早期发现和治疗相关恶性肿瘤的兴趣日益浓厚。我们旨在简要综述BRCA-1相关蛋白1及其在致癌作用中的作用、BRCA-1相关蛋白1癌症易感性综合征，并讨论临床意义，包括建议的筛查指南和潜在的靶向治疗选择。
