2016 - 2017年巴西有记录以来最大规模黄热病疫情期间，与黄热病疫苗接种后不良事件严重程度相关的因素。
Factors associated with severity of adverse events following yellow fever vaccination during the biggest outbreak of the disease recorded in Brazil, 2016-2017.
作者信息
Lucena Adriana Regina Farias Pontes, Souza Líbia Roberta de Oliveira, Percio Jadher, Carvalho Sandra Maria Deotti, Romano Alessandro Pecego Martins, Domingues Carla Magda Allan Santos
机构信息
Ministério da Saúde, Secretaria de Vigilância em Saúde, Brasília, DF, Brasil.
出版信息
Epidemiol Serv Saude. 2020 Mar 23;29(1):e2018331. doi: 10.5123/S1679-49742020000100017. eCollection 2020.
OBJECTIVE
to analyze characteristics, incidence and factors associated with serious adverse events (SAEs) following yellow fever vaccination during an outbreak of the disease in Brazil (2016-2017).
METHODS
this was a case-control study using data from the National Immunization Program Information System (SI-PNI); SAE were considered to be cases, and non-serious adverse events (NSAE) were considered to be controls.
RESULTS
we analyzed 135 SAE cases and 1,058 controls; of the 135 SAE, 79 (58.5%) were males and median age was 28 years [09-49]; incidence in January 2017 reached 1.3 case per 100,000 vaccine doses administered; there was statistical association with males (Odds Ratio [OR]=1.73 - 95%CI 1.20;2.48), primary vaccination (OR=1.65 - 95%CI 1.01;2.71), and being 60 years of age or older taking as reference those aged under 5 (OR=4.4; p-value <0.02).
CONCLUSION
SAE owing to yellow fever vaccine showed a greater chance of occurring in men, the elderly and primary vaccination.
目的
分析巴西黄热病疫情爆发期间（2016 - 2017年）黄热病疫苗接种后严重不良事件（SAE）的特征、发生率及相关因素。
方法
这是一项病例对照研究，使用国家免疫规划信息系统（SI-PNI）的数据；SAE被视为病例，非严重不良事件（NSAE）被视为对照。
结果
我们分析了135例SAE病例和1058例对照；在135例SAE中，79例（58.5%）为男性，中位年龄为28岁[09 - 49]；2017年1月的发生率达到每10万剂疫苗接种中有1.3例；与男性（优势比[OR]=1.73 - 95%CI 1.20;2.48）、初次接种（OR=1.65 - 95%CI 1.01;2.71）以及以5岁以下者为参照的60岁及以上者（OR=4.4；p值<0.02）存在统计学关联。
结论
黄热病疫苗导致的SAE在男性、老年人及初次接种者中发生的可能性更大。
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