School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China.
Newish Technology (Beijing) Co., Ltd., Xihuan South Road 18, Economic & Technical Development Zone, Beijing, 100176, China.
Protein Cell. 2020 Aug;11(8):549-564. doi: 10.1007/s13238-020-00707-9. Epub 2020 Mar 27.
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This review focuses on recent advances in efficacy against tumors, the origin, formation mechanisms of memory T cells, and the role of the gut microbiota in memory T cell formation. Furthermore, we summarize strategies to generate memory T cells in (ex) vivo that, might be applicable in clinical practice.
几项研究表明，与效应记忆 T（Tem）细胞和效应 T（Teff）细胞相比，记忆 T 细胞包括干细胞记忆（Tscm）T 细胞和中央记忆（Tcm）T 细胞表现出更好的持久性和抗肿瘤免疫。此外，Tcm/Teff 比值已被报道为一些肿瘤免疫反应的预测生物标志物。因此，系统地了解效应和记忆 T 细胞分化的机制对于开发针对各种肿瘤的免疫策略变得越来越重要。本综述重点介绍了针对肿瘤的治疗效果、记忆 T 细胞的起源和形成机制以及肠道微生物群在记忆 T 细胞形成中的作用的最新进展。此外，我们总结了在（ex）体内生成记忆 T 细胞的策略，这些策略可能适用于临床实践。
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