NUCB2/nesfatin-1- 对摄食、体重和代谢的抑制作用。
NUCB2/nesfatin-1 - Inhibitory effects on food intake, body weight and metabolism.
机构信息
Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Laboratory of Integrative Neuroendocrinology, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
出版信息
Peptides. 2020 Jun;128:170308. doi: 10.1016/j.peptides.2020.170308. Epub 2020 Mar 27.
Since its discovery in 2006 by Oh-I and colleagues, NUCB2/nesfatin-1 encoded by nucleobindin-2 (NUCB2) has drawn sustained attention as reflected in over 500 publications. Among those, more than half focused on the alterations of food intake, body weight and metabolism (glucose, fat) induced by nesfatin-1 and/or NUCB2/nesfatin-1. In the current review we discuss the existing literature focusing on NUCB2/nesfatin-1's influence on food intake, body weight and glucose as well as fat metabolism and highlight gaps in knowledge.
自 2006 年 Oh-I 及其同事发现以来，核蛋白结合蛋白 2（NUCB2）编码的 NUCB2/nesfatin-1 作为反映在 500 多篇出版物中的持续关注的焦点。其中，超过一半的研究集中在 nesfatin-1 和/或 NUCB2/nesfatin-1 诱导的食物摄入、体重和代谢（葡萄糖、脂肪）的改变上。在本综述中，我们讨论了现有的文献，重点介绍了 NUCB2/nesfatin-1 对食物摄入、体重和葡萄糖以及脂肪代谢的影响，并强调了知识上的差距。
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