体重指数（BMI）与血液或正常成人乳腺组织中 DNA 甲基化的关联：系统综述。

Association Between BMI and DNA Methylation in Blood or Normal Adult Breast Tissue: A Systematic Review.

机构信息

Department of Social and Preventive Medicine, Cancer Research Center, Faculty of Medicine, Laval University, Quebec City, QC, Canada.

CHU de Québec Research Center-Laval University, Quebec City, QC, Canada.

出版信息

Anticancer Res. 2020 Apr;40(4):1797-1808. doi: 10.21873/anticanres.14134.

DOI:10.21873/anticanres.14134

PMID:32234868

Abstract

BACKGROUND/AIM: Several studies have investigated the influence of obesity on DNA methylation (DNAm) to find biomarkers associated with the detection of chronic diseases, including breast cancer. The aim of the study was to systematically review studies examining the association of body mass index (BMI) and DNAm in blood or normal breast tissue.

MATERIALS AND METHODS

Three scientific literature databases (PubMed, Embase and Web of Science) were screened until May 2018.

RESULTS

Twenty-four studies were included along with ours in which we investigated this relation in the normal breast tissue of 40 breast cancer patients.

CONCLUSION

BMI-associated CpG sites were highly variable with few identified in less than half of the studies. Nevertheless, a few genes potentially associated with BMI were highlighted in blood (CPT1A, ABCG1, SREBF1 and LGALS3BP) and in normal breast tissue (PTPRN2 and ABLIM2). The variability of the results could be explained by the tissue and cell-specificity of methylation and differences in methodology.

摘要

背景/目的：多项研究调查了肥胖对 DNA 甲基化（DNAm）的影响，以寻找与慢性疾病（包括乳腺癌）检测相关的生物标志物。本研究旨在系统地综述研究 BMI 和血液或正常乳腺组织中 DNAm 之间关系的研究。

材料和方法

直到 2018 年 5 月，我们在三个科学文献数据库（PubMed、Embase 和 Web of Science）中进行了筛选。

结果

共纳入 24 项研究，其中包括我们对 40 名乳腺癌患者正常乳腺组织中这种关系的研究。

结论

与 BMI 相关的 CpG 位点差异很大，只有不到一半的研究中确定了少数几个。尽管如此，在血液（CPT1A、ABCG1、SREBF1 和 LGALS3BP）和正常乳腺组织（PTPRN2 和 ABLIM2）中还是发现了一些可能与 BMI 相关的基因。结果的可变性可能是由于甲基化的组织和细胞特异性以及方法学的差异造成的。