Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Can J Diabetes. 2020 Jul;44(5):394-400. doi: 10.1016/j.jcjd.2019.12.001. Epub 2020 Jan 7.
Although national guidelines advocate for earlier diabetes screening in high-risk ethnic groups, little evidence exists to guide clinicians on the age at which screening should commence. The purpose of this study was to determine age equivalency thresholds for diabetes risk across a broad range of ethnic populations.
This population-based, retrospective cohort study used linked administrative health and immigration records for 592,376 individuals in Ontario, Canada. Adjusted incidence rates by ethnicity, sex and age were used to derive ethnic-specific age thresholds for risk.
Diabetes incidence rates in South Asians reached an equivalent risk as that experienced by a 40-year-old Western European man (3.7 per 1,000 person-years) by 25 years of age. For all other non-European ethnic groups, the equivalent risk was experienced between 30 and 35 years of age. These risk differentials persisted despite controlling for covariates.
We found a 15-year difference in age equivalency of risk across ethnic groups.
尽管国家指南提倡对高危族裔进行更早的糖尿病筛查，但几乎没有证据可以指导临床医生确定筛查开始的年龄。本研究的目的是确定广泛族裔人群中糖尿病风险的年龄等效阈值。
本基于人群的回顾性队列研究使用了加拿大安大略省的链接行政健康和移民记录，涉及 592376 人。按族裔、性别和年龄调整发病率，得出族裔特异性风险年龄阈值。
南亚人的糖尿病发病率在 25 岁时达到与西欧男性（3.7 人/1000人年）相同的风险水平。对于所有其他非欧洲族裔，等效风险发生在 30 至 35 岁之间。尽管控制了协变量，但这些风险差异仍然存在。
我们发现，不同族裔之间的风险年龄等效性存在 15 年的差异。
