点击型杯芳烃以获取多价结构。
Clickable Bambusurils to Access Multivalent Architectures.
机构信息
Université Paris-Saclay, CEA, Service de Chimie Bio-organique et de Marquage, 91191 Gif-sur-Yvette, France.
Université Paris-Saclay, CEA, Service Hospitalier Frédéric Joliot, IMIV, 91401 Orsay, France.
出版信息
Org Lett. 2020 Apr 17;22(8):3099-3103. doi: 10.1021/acs.orglett.0c00856. Epub 2020 Apr 3.
Propargylated bambus[4,6]urils were prepared by an efficient one-step condensation of dipropargylglycoluril with formaldehyde under microwave irradiation. Their functionalization by click chemistry (CuAAC) afforded new multivalent architectures decorated with 8 or 12 ligands. Grafting of glycosides provided water-soluble glycobambus[4,6]uril platforms with glucosylBU[6] showing good affinity toward iodide anion in aqueous medium.
炔丙基化的 bambus[4,6]尿嘧啶通过二丙炔基甘脲与甲醛在微波辐射下的高效一步缩合反应制备。通过点击化学（CuAAC）对其官能化，得到了新的多价结构，这些结构用 8 或 12 个配体进行了装饰。糖基的接枝提供了水溶性的糖基 bambus[4,6]尿嘧啶平台，其中葡糖基 BU[6]在水介质中对碘阴离子表现出良好的亲和力。
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