Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Cell Stem Cell. 2020 Apr 2;26(4):469-471. doi: 10.1016/j.stem.2020.03.007.
In this issue of Cell Stem Cell, Fumagalli et al. (2020) employ intravital microscopy of colorectal cancer organoid xenografts to investigate the cell of origin of metastases. While tumor-initiating cells are Lgr5, most disseminated cancer cells are Lgr5 and seed liver metastases in which Lgr5 cells then appear, showing that bidirectional plasticity of phenotypic states drives metastasis.
本期《细胞—干细胞》杂志,Fumagalli 等人(2020 年)运用结直肠癌细胞球体异种移植的活体显微镜检查,研究了转移的起始细胞。虽然肿瘤起始细胞是 Lgr5,但大多数扩散的癌细胞也是 Lgr5,并在其中播种肝转移,然后 Lgr5 细胞出现,表明表型状态的双向可塑性驱动转移。