Department of Psychology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Department of Neurological Surgery, University of California, San Francisco, CA, 94122, USA.
Nat Commun. 2020 Apr 3;11(1):1682. doi: 10.1038/s41467-020-15442-2.
When learning about dynamic and uncertain environments, people should update their beliefs most strongly when new evidence is most informative, such as when the environment undergoes a surprising change or existing beliefs are highly uncertain. Here we show that modulations of surprise and uncertainty are encoded in a particular, temporally dynamic pattern of whole-brain functional connectivity, and this encoding is enhanced in individuals that adapt their learning dynamics more appropriately in response to these factors. The key feature of this whole-brain pattern of functional connectivity is stronger connectivity, or functional integration, between the fronto-parietal and other functional systems. Our results provide new insights regarding the association between dynamic adjustments in learning and dynamic, large-scale changes in functional connectivity across the brain.
当人们学习动态和不确定的环境时，他们应该在新证据最具信息量时最强地更新他们的信念，例如当环境发生令人惊讶的变化或现有信念高度不确定时。在这里，我们表明，惊讶和不确定性的调制被编码在大脑整体功能连接的特定的、时间动态的模式中，并且这种编码在那些更适当地响应这些因素来调整他们的学习动态的个体中得到增强。这种大脑整体功能连接的模式的关键特征是额顶叶和其他功能系统之间更强的连接或功能整合。我们的研究结果提供了关于学习的动态调整与大脑中大规模功能连接的动态变化之间关联的新见解。
