Zhang Shaohan, Xin Peikun, Ou Qianmin, Hollett Geoffrey, Gu Zhipeng, Wu Jun
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510006, China.
J Mater Chem B. 2018 Nov 14;6(42):6723-6730. doi: 10.1039/c8tb01466c. Epub 2018 Oct 5.
Transdermal drug delivery is an attractive, non-invasive treatment. It can avoid first-pass hepatic metabolism and provides the possibility of self-administration. Hydrogels are promising biomaterials due to their important qualities such as biocompatibility and biodegradability. Recently, there has been tremendous growth in the area of hydrogels for transdermal drug delivery. In this work, a new kind of arginine-based poly(ester amide) (Arg-PEA) and polyethylene glycol diacrylamide (PEG-DA) hybrid hydrogel was developed for transdermal drug delivery. The hydrogels not only possess excellent swelling capacity, but also have good mechanical properties, which were then evaluated as drug delivery agents using insulin as a model system. Cytotoxicity testing and in vivo skin irritation tests demonstrated that the hydrogels were biocompatible. Finally, the results indicated that the prepared hydrogels could not only perform transdermal drug delivery, but also might regulate blood glucose levels in a mouse model with streptozotocin-induced diabetes.
经皮给药是一种有吸引力的非侵入性治疗方法。它可以避免肝脏首过代谢，并提供自我给药的可能性。水凝胶因其生物相容性和可生物降解性等重要特性而成为有前景的生物材料。最近，用于经皮给药的水凝胶领域有了巨大的发展。在这项工作中，开发了一种新型的基于精氨酸的聚（酯酰胺）（Arg-PEA）和聚乙二醇二丙烯酸酯（PEG-DA）混合水凝胶用于经皮给药。这些水凝胶不仅具有出色的溶胀能力，还具有良好的机械性能，然后以胰岛素为模型系统将其评估为药物递送剂。细胞毒性测试和体内皮肤刺激性测试表明这些水凝胶具有生物相容性。最后，结果表明所制备的水凝胶不仅可以进行经皮给药，还可能在链脲佐菌素诱导的糖尿病小鼠模型中调节血糖水平。
