Nanbu Y, Fujii S, Konishi I, Nonogaki H, Kobayashi F, Sagawa N, Mori T
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 Oct;40(10):1519-24.
Recently, normal cervical glandular cells have been reported to synthesize and secrete CA125 as a common constituent of normal cervical mucus. However, the levels of CA125 in the cervical mucus samples during the menstrual cycle and with cervical inflammatory diseases have not been determined. Therefore, we measured CA125 in cervical mucus samples in various phases of the menstrual cycle and in patients with cervical polyp or vaginitis. In addition to CA125, CEA and CA19-9 were also examined in the same samples. CA125 levels in the mucus samples of women (45 cases) without any gynecologic disorders (control) were 102,200 +/- 8,600 (M +/- S.E.) U/ml. Significantly higher levels were noted in the samples obtained in the follicular phase than in the luteal phase. CA125 levels in the mucus with atrophic vaginitis (12 cases) were significantly lower than those of controls. CEA and CA19-9 levels in the control samples were 3,400 +/- 550 ng/ml and 3,470 +/- 500 U/ml, respectively, and both of these showed no significant difference between the follicular and luteal phases. However, both CEA and CA19-9 levels in the cervical mucus with cervical polyps (15 cases) or vaginitis were much higher than in the controls. Accordingly, the present study revealed that CA125 in the cervical mucus fluctuates during the menstrual cycle, probably under the influence of ovarian sex steroids. In addition, CEA and CA19-9 in the cervical mucus samples obtained from women without any gynecologic disorders showed low levels, but those with inflammatory diseases were high, and this suggested that inflammatory diseases in the cervix and/or vagina may affect the constituent of the tumor-associated carbohydrate antigens in the cervical mucus.
最近，有报道称正常宫颈腺细胞可合成并分泌CA125，作为正常宫颈黏液的常见成分。然而，月经周期中和患有宫颈炎症疾病时宫颈黏液样本中CA125的水平尚未确定。因此，我们测量了月经周期各阶段以及宫颈息肉或阴道炎患者宫颈黏液样本中的CA125。除CA125外，还在相同样本中检测了癌胚抗原（CEA）和糖类抗原19-9（CA19-9）。45例无任何妇科疾病（对照组）女性的黏液样本中CA125水平为102,200±8,600（均值±标准误）U/ml。卵泡期样本中的CA125水平显著高于黄体期。萎缩性阴道炎患者（12例）黏液中的CA125水平显著低于对照组。对照组样本中CEA和CA19-9水平分别为3,400±550 ng/ml和3,470±500 U/ml，二者在卵泡期和黄体期之间均无显著差异。然而，宫颈息肉患者（15例）或阴道炎患者宫颈黏液中的CEA和CA19-9水平均远高于对照组。因此，本研究表明宫颈黏液中的CA125在月经周期中波动，可能受卵巢性甾体激素影响。此外，无任何妇科疾病女性的宫颈黏液样本中CEA和CA19-9水平较低，但患有炎症疾病的女性其水平较高，这表明宫颈和/或阴道的炎症疾病可能影响宫颈黏液中肿瘤相关碳水化合物抗原的成分。
