Treede R D, Meier W, Kunze K, Bromm B
Institute of Physiology, University Hospital Eppendorf, Hamburg, FRG.
J Neurol Neurosurg Psychiatry. 1988 Oct;51(10):1330-3. doi: 10.1136/jnnp.51.10.1330.
Evoked cerebral potentials were investigated in a patient with neurosyphilis, who showed the symptoms of delayed pain perception in the lower limbs: a pinprick to the legs was perceived with a latency of more than one second. After stimulation with CO2 laser radiant heat pulses, evoked cerebral potentials of upper limbs were observed in a latency range comparable to those of healthy subjects, with a negative peak at 250 ms and a positive peak at 370 ms. In contrast, after application of laser stimuli to body sites with delayed pain perception, latency of the evoked potentials drastically increased with a vertex negativity at 1300 ms and a positivity at 1420 ms. Evoked potential measurements with conventional electrical stimuli did not show any difference between affected and unaffected body sites, that is, stimulation of the affected body sites did not produce pathological potentials.
对一名患有神经梅毒的患者进行了诱发脑电位研究，该患者表现出下肢疼痛感知延迟的症状：用针刺腿部时，潜伏期超过一秒才会有感觉。在用二氧化碳激光辐射热脉冲刺激后，观察到上肢诱发脑电位的潜伏期范围与健康受试者相当，在250毫秒时有一个负峰，在370毫秒时有一个正峰。相比之下，在用激光刺激疼痛感知延迟的身体部位后，诱发电位的潜伏期急剧增加，在1300毫秒时有一个顶点负电位，在1420毫秒时有一个正电位。用传统电刺激进行的诱发电位测量显示，受影响和未受影响的身体部位之间没有任何差异，也就是说，刺激受影响的身体部位不会产生病理电位。
