Cruz M S, Santillan J, Lesser J, Ortiz J, Forzani L, Plaza P
Fundación de la Hemofilia de Salta, Salta, Argentina.
Case Rep Hematol. 2020 Mar 18;2020:4852428. doi: 10.1155/2020/4852428. eCollection 2020.
An increased incidence of haematologic malignancies and other cancer types among patients with haemophilia compared with matched controls has been reported in several longitudinal studies. Tumours initially misdiagnosed as haematomas and conversely haematomas mistaken for tumours have been reported. Here, we describe the case of a 43-year-old man with severe haemophilia A and a diffuse large B-cell lymphoma, originally diagnosed as a haematoma, who underwent a splenectomy and several associated surgeries as part of his lymphoma treatment. Perioperative treatment with octanate® (human coagulation factor VIII) enabled the successful performance of all surgical interventions required in the context of lymphoma treatment. Nevertheless, differential diagnosis of posttraumatic haematoma in patients with haemophilia should include the consideration of malignancy.
多项纵向研究报告称，与匹配的对照组相比，血友病患者血液系统恶性肿瘤和其他癌症类型的发病率有所增加。有报告称，肿瘤最初被误诊为血肿，反之，血肿被误认为肿瘤。在此，我们描述了一例43岁重度甲型血友病男性患者，其患有弥漫性大B细胞淋巴瘤，最初被诊断为血肿，作为淋巴瘤治疗的一部分，他接受了脾切除术及几次相关手术。使用奥曲安（人凝血因子VIII）进行围手术期治疗，使淋巴瘤治疗所需的所有外科手术得以成功实施。尽管如此，血友病患者创伤后血肿的鉴别诊断应考虑到恶性肿瘤的可能性。
