描述α7烟碱型乙酰胆碱受体（α7nAChR）刺激后ApoE基因敲除小鼠主动脉转录变化的RNA测序数据。
RNA sequencing data describing transcriptional changes in aorta of ApoE-/- mice after alpha 7 nicotinic acetylcholine receptor (α7nAChR) stimulation.
作者信息
Ulleryd Marcus A, Mjörnstedt Filip, Panagaki Dimitra, Yang Li Jin, Engevall Kajsa, Gutierrez Saray, Wang Yixin, Gan Li-Ming, Nilsson Holger, Michaëlsson Erik, Johansson Maria E
机构信息
Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Crown Bioscience Inc., Shanghai, China.
出版信息
Data Brief. 2020 Mar 12;30:105415. doi: 10.1016/j.dib.2020.105415. eCollection 2020 Jun.
This manuscript is a companion paper to Ulleryd M.U. et al., Atherosclerosis, 2019 [1]. Data shown here include RNA sequencing data from whole aorta of ApoE-/- mice fed high fat diet and treated with the alpha 7 nicotinic acetylcholine receptor (α7nAChR) agonist AZ6983 for 8 weeks using subcutaneously implanted osmotic minipumps. Here we present the top gene networks affected by treatment with AZ6983, as well as the up- and down-regulated genes in aorta after treatment. Further, a URL link to the RNA sequencing datasets submitted to GEO is included.
本手稿是Ulleryd M.U.等人于2019年发表在《动脉粥样硬化》杂志上的一篇配套论文[1]。此处展示的数据包括来自喂食高脂饮食并使用皮下植入式渗透微型泵用α7烟碱型乙酰胆碱受体（α7nAChR）激动剂AZ6983处理8周的ApoE-/-小鼠全主动脉的RNA测序数据。在此，我们展示了受AZ6983处理影响的顶级基因网络，以及处理后主动脉中上调和下调的基因。此外，还包含了提交至GEO的RNA测序数据集的URL链接。
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