Chidambaranathan-Reghupaty Saranya, Mendoza Rachel, Fisher Paul B, Sarkar Devanand
Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Hepatoma Res. 2018;4. doi: 10.20517/2394-5079.2018.34. Epub 2018 Jul 10.
Staphylococcal nuclease and tudor domain containing 1 (SND1) is a protein that regulates a complex array of functions. It controls gene expression through transcriptional activation, mRNA degradation, mRNA stabilization, ubiquitination and alternative splicing. More than two decades of research has accumulated evidence of the role of SND1 as an oncogene in various cancers. It is a promoter of cancer hallmarks like proliferation, invasion, migration, angiogenesis and metastasis. In addition to these functions, it has a role in lipid metabolism, inflammation and stress response. The participation of SND1 in such varied functions makes it distinct from most oncogenes that are relatively more focused in their role. This becomes important in the case of hepatocellular carcinoma (HCC) since in addition to typical cancer drivers, factors like lipid metabolism deregulation and chronic inflammation can predispose hepatocytes to HCC. The objective of this review is to provide a summary of the current knowledge available on SND1, specifically in relation to HCC and to shed light on its prospect as a therapeutic target.
含葡萄球菌核酸酶和 Tudor 结构域 1（SND1）是一种调节一系列复杂功能的蛋白质。它通过转录激活、mRNA 降解、mRNA 稳定、泛素化和可变剪接来控制基因表达。二十多年的研究积累了证据，证明 SND1 在各种癌症中作为癌基因的作用。它是癌症特征（如增殖、侵袭、迁移、血管生成和转移）的促进因子。除了这些功能外，它还在脂质代谢、炎症和应激反应中发挥作用。SND1 参与如此多样的功能，使其有别于大多数作用相对更具针对性的癌基因。在肝细胞癌（HCC）的情况下，这一点变得很重要，因为除了典型的癌症驱动因素外，脂质代谢失调和慢性炎症等因素会使肝细胞易患 HCC。本综述的目的是总结目前关于 SND1 的现有知识，特别是与 HCC 相关的知识，并阐明其作为治疗靶点的前景。
