Gilbert Rose, Al-Janabi Ahmed, Tomkins-Netzer Oren, Lightman Sue
Moorfields Eye Hospital, London, UK.
University College London (UCL) Institute of Ophthalmology, London, UK.
Porto Biomed J. 2017 Mar-Apr;2(2):33-39. doi: 10.1016/j.pbj.2017.01.006. Epub 2017 Mar 1.
In addition to the known lipid-lowering effects, statins are now widely accepted to have anti-inflammatory and immunomodulatory effects. Adjunctive use of statins has proven beneficial in the context of a wide range of inflammatory diseases, including rheumatoid arthritis. Evidence also suggests that statins may also have utility in the management of uveitis, a form of sight threatening inflammation which occurs in the eye. In this article, we outline our rationale behind a clinical trial of simvastatin as a steroid-sparing agent in uveitis, to which patient recruitment started last year. Potential risks associated with the clinical use of statins, including putative effects on the eyes, are discussed.
除了已知的降脂作用外，他汀类药物现在已被广泛认为具有抗炎和免疫调节作用。事实证明，在包括类风湿性关节炎在内的多种炎症性疾病中，辅助使用他汀类药物是有益的。有证据还表明，他汀类药物在葡萄膜炎的治疗中可能也有作用，葡萄膜炎是一种发生在眼睛的、威胁视力的炎症。在本文中，我们概述了将辛伐他汀作为葡萄膜炎中一种节省类固醇药物进行临床试验的基本原理，该试验已于去年开始招募患者。我们还讨论了与他汀类药物临床使用相关的潜在风险，包括对眼睛的假定影响。
