Yue Qin, Wang Minghong, Sun Zhenkun, Wang Chun, Wang Can, Deng Yonghui, Zhao Dongyuan
Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State key laboratory of molecular engineering of polymers and Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P. R. China.
J Mater Chem B. 2013 Nov 28;1(44):6085-6093. doi: 10.1039/c3tb21028f. Epub 2013 Oct 8.
A versatile ethanol-mediated oxidative polymerization of dopamine is demonstrated for the effective surface modification of nanomaterials. The presence of ethanol is found to significantly slow down the polymerization rate of dopamine and make the surface modification of nanomaterials with polydopamine more controllable in comparison to the water-phase polymerization. Various nanomaterials with different morphologies and surface properties, including one-dimensional (1-D) CNTs and iron oxide nanorods, 2-D nanodiscs, silver nanocubes and magnetite particles, were successfully modified by a layer of PDA with a controllable thickness from 5 to 100 nm, giving rise to PDA-shelled nanocomposites with well-defined structures and excellent water dispersibility. As exemplified by the case of magnetite particles, the PDA coating can dramatically reduce the cytotoxicity of nanomaterials and enhance their biocompatibility. This method is facile and particularly suitable for the surface engineering of nanomaterials, and thus promising for designing various functional nanostructures for a broad range of applications, such as drug delivery, protein purification, enzyme immobilization, and chemo/biosensing.
已证明多巴胺的乙醇介导通用氧化聚合可用于纳米材料的有效表面改性。发现乙醇的存在会显著减缓多巴胺的聚合速率，并且与水相聚合相比，使聚多巴胺对纳米材料的表面改性更可控。各种具有不同形态和表面性质的纳米材料，包括一维（1-D）碳纳米管和氧化铁纳米棒、二维纳米盘、银纳米立方体和磁铁矿颗粒，成功地被一层厚度可控在5至100纳米的聚多巴胺改性，从而产生具有明确结构和优异水分散性的聚多巴胺壳纳米复合材料。以磁铁矿颗粒为例，聚多巴胺涂层可显著降低纳米材料的细胞毒性并增强其生物相容性。该方法简便易行，特别适用于纳米材料的表面工程，因此有望设计出用于广泛应用的各种功能纳米结构，如药物递送、蛋白质纯化、酶固定化以及化学/生物传感。
