水性介质中基于葡聚糖的单链纳米颗粒的合成与功能化
Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media.
作者信息
Gracia R, Marradi M, Cossío U, Benito A, Pérez-San Vicente A, Gómez-Vallejo V, Grande H-J, Llop J, Loinaz I
机构信息
Biomaterials Unit, IK4-CIDETEC, Po Miramón 196, 20014, Donostia-San Sebastián, Spain.
出版信息
J Mater Chem B. 2017 Feb 14;5(6):1143-1147. doi: 10.1039/c6tb02773c. Epub 2017 Jan 30.
Water-dispersible dextran-based single-chain polymer nanoparticles (SCPNs) were prepared in aqueous media and under mild conditions. Radiolabeling of the resulting biocompatible materials allowed the study of lung deposition of aqueous aerosols after intratracheal nebulization by means of single-photon emission computed tomography (SPECT), demonstrating their potential use as imaging contrast agents.
在水性介质中且在温和条件下制备了基于可水分散的葡聚糖的单链聚合物纳米颗粒（SCPNs）。对所得生物相容性材料进行放射性标记后，借助单光子发射计算机断层扫描（SPECT）研究了气管内雾化后水性气雾剂在肺部的沉积情况，证明了它们作为成像造影剂的潜在用途。
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