肠道微生物群与放射性碘难治性甲状腺乳头状癌的病理生理学
Gut Microbiome and Radioiodine-Refractory Papillary Thyroid Carcinoma Pathophysiology.
机构信息
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran; Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center (EMRC), Dr. Shariati Hospital, Tehran, Iran.
出版信息
Trends Endocrinol Metab. 2020 Sep;31(9):627-630. doi: 10.1016/j.tem.2020.03.005. Epub 2020 Apr 6.
Gut microbiome (GM) might be associated with radioiodine (RAI)-refractory papillary thyroid carcinoma (PTC) through different mechanisms related to sodium/iodide (Na/I) symporter (NIS) regulation. However, whether thyroid carcinoma (TC), especially RAI-refractory PTC, causes dysbiosis, or vice versa, is still unknown. Further studies are needed to investigate the mechanism between GM and RAI-refractory PTC.
肠道微生物组（GM）可能通过与钠/碘（Na/I）转运体（NIS）调节相关的不同机制与放射性碘（RAI）难治性甲状腺乳头状癌（PTC）相关。然而，甲状腺癌（TC），特别是 RAI 难治性 PTC 是否会导致肠道菌群失调，或者反之亦然，目前尚不清楚。需要进一步研究来探讨 GM 和 RAI 难治性 PTC 之间的机制。
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