左心房容积、排空分数、应变和应变率及其与年龄、性别和种族相关的参考值：动脉粥样硬化多民族研究（MESA）。
References Values for Left Atrial Volumes, Emptying Fractions, Strains, and Strain Rates and Their Determinants by Age, Gender, and Ethnicity: The Multiethnic Study of Atherosclerosis (MESA).
机构信息
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 524, Baltimore, Maryland 21287-8222.
Division of Cardiology, Department of Medicine, University of New Mexico, Albuquerque, New Mexico.
出版信息
Acad Radiol. 2021 Mar;28(3):356-363. doi: 10.1016/j.acra.2020.02.010. Epub 2020 Apr 9.
RATIONALE AND OBJECTIVES
Left Atrial (LA) adverse remodeling is an important predictor of morbidity and mortality in several cardiovascular (CV) diseases. Our goals were to quantify and provide reference ranges for LA structure and function using feature tracking cine cardiac magnetic resonance.
MATERIALS AND METHODS
2526 participants of the Multiethnic Study of Atherosclerosis study who had feature tracking cine cardiac magnetic resonance derived LA data and were free of atrial fibrillation/flutter and prior CV events at year five follow-up examination (2010-2012) were included in this study. LA phasic indexed volumes: maximum (LAVi max), minimum (LAVi min), and preatrial contraction (LAVi preA); LA empty fractions: total, passive, and active (LAtEF, LApEF, and LAaEF); LA longitudinal strain: maximum and preatrial contraction (S max and S preA); and LA longitudinal strain rate: systolic (SR max) and early/late diastolic (SR e and SR a) were measured. Age, gender, and race/ethnicity-specific reference ranges were identified. Also, reference values in a select subgroup of healthy participants free of traditional CV risk factors at the time of exam date were reported.
RESULTS
The mean ± SD for LAVi max, LAVi min, LAVi preA, S max, SR e, and SR a were in the 45-65-year-old participants: (33.8 ± 10 mL/m), (14.5 ± 6.4 mL/m), (24.8 ± 8.2 mL/m), (34.6 ± 13.8 %), (-1.4 ± 0.7 s), (-2.1 ± 1 s) and in the ≥ 65-year-old participants: (35 ± 11.5 mL/m2), (16.6 ± 8.3 mL/m2), (27.6 ± 9.9 mL/m2), (31.2 ± 14.3 %), (-1 ± 0.6 s), (-2.1 ± 1 s) respectively. Younger individuals had Powered by Editorial Manager and ProduXion Manager from Aries Systems Corporation smaller LA volumes and better LA function compared to their older counterparts. Similar findings were observed in Chinese-Americans as compared to Whites.
CONCLUSION
This study provides reference values of LA structure and function parameters from a healthy multiethnic community-based population aged 53-94 years evaluated by FTMRI.
背景与目的
左心房（LA）重构不良是多种心血管疾病发病率和死亡率的重要预测指标。我们的目标是使用特征追踪电影心脏磁共振定量和提供 LA 结构和功能的参考范围。
材料与方法
这项研究纳入了 2526 名多民族动脉粥样硬化研究参与者，这些参与者在 5 年随访检查（2010-2012 年）时具有特征追踪电影心脏磁共振衍生的 LA 数据，并且无心房颤动/扑动和既往心血管事件。测量 LA 时相指数容积：最大（LAVi max）、最小（LAVi min）和房事前收缩（LAVi preA）；LA 排空分数：总排空、被动排空和主动排空（LAtEF、LApEF 和 LAaEF）；LA 纵向应变：最大和房事前收缩（S max 和 S preA）；LA 纵向应变率：收缩期（SR max）和早期/晚期舒张期（SR e 和 SR a）。确定了年龄、性别和种族/民族特异性参考范围。此外，还报告了在检查日期时无传统心血管危险因素的健康参与者的亚组中的参考值。
结果
在 45-65 岁的参与者中，LAVi max、LAVi min、LAVi preA、S max、SR e 和 SR a 的平均值±标准差分别为：（33.8±10 ml/m）、（14.5±6.4 ml/m）、（24.8±8.2 ml/m）、（34.6±13.8）%、（-1.4±0.7 s）、（-2.1±1 s），在≥65 岁的参与者中分别为：（35±11.5 ml/m2）、（16.6±8.3 ml/m2）、（27.6±9.9 ml/m2）、（31.2±14.3）%、（-1±0.6 s）、（-2.1±1 s）。与年龄较大的参与者相比，年轻参与者的 LA 容积较小，LA 功能更好。与白人相比，美籍亚裔也有类似的发现。
结论
本研究提供了年龄在 53-94 岁之间的健康多民族社区人群的 LA 结构和功能参数的参考值，这些参数是通过 FTMRI 评估的。
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