Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Reprod Toxicol. 2020 Jun;94:31-39. doi: 10.1016/j.reprotox.2020.03.011. Epub 2020 Apr 10.
Exposure to the man-made chemicals perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and perfluorohexanesulfonate (PFHxS) is widespread. These perfluoroalkyl substances (PFASs) have been associated with androgenic endocrine-disrupting properties; however, the evidence is equivocal and few human studies have examined the association between prenatal exposure to PFASs and markers of androgenic endocrine disruption such as changes in anogenital distance (AGD). In the MIREC cohort, PFOA, PFOS and PFHxS were analyzed in first trimester maternal plasma. AGD was measured in 205 male and 196 female newborns. The change in estimate procedure was used to identify confounders by sex and AGD in multiple linear regression models. Geometric mean plasma concentrations (95% CI) for PFOA, PFOS and PFHxS were 1.71 (1.61, 1.81), 4.40 (4.18, 4.64) and 1.15 (1.06, 1.25) μg/L, respectively. A one-unit increase in natural log transformed PFOA was associated with a 1.36 mm (95% CI 0.30, 2.41) increase in anoscrotal distance, adjusting for household income, active smoking status during pregnancy and gestational age. However, when examined by quartiles, a non-monotonic pattern was observed with wide confidence intervals. No consistent patterns were observed between maternal PFAS concentrations and female AGDs. This study found no clear evidence that maternal plasma concentrations of PFOS, PFOA or PFHxS were associated with shorter infant anogenital distance in males or any change in AGD in females. Whether the positive association observed between longer anoscrotal distance and PFOA is real or would have any long-lasting effect on the reproductive health of males is unknown and needs to be investigated further.
接触人造化学品全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）和全氟己烷磺酸（PFHxS）较为普遍。这些全氟烷基物质（PFAS）与雄性激素内分泌干扰特性有关；然而，证据尚无定论，并且很少有人类研究调查了产前暴露于 PFAS 与雄性激素内分泌干扰标志物（如肛门生殖器距离（AGD）的变化）之间的关联。在 MIREC 队列中，在妊娠早期母亲血浆中分析了 PFOA、PFOS 和 PFHxS。在 205 名男性和 196 名女性新生儿中测量了 AGD。通过性别和 AGD 对多元线性回归模型中的混杂因素进行了估计程序的变化识别。PFOA、PFOS 和 PFHxS 的几何平均血浆浓度（95%CI）分别为 1.71（1.61，1.81）、4.40（4.18，4.64）和 1.15（1.06，1.25）μg/L。自然对数转化的 PFOA 每增加一个单位，肛门生殖器距离增加 1.36 毫米（95%CI 0.30，2.41），调整了家庭收入、妊娠期间主动吸烟状况和胎龄。然而，当按四分位数进行检查时，观察到了非单调模式，置信区间较宽。在女性 AGD 中，母亲 PFAS 浓度与女性 AGD 之间没有一致的模式。本研究没有明确证据表明母亲血浆中 PFOS、PFOA 或 PFHxS 浓度与男性的婴儿肛门生殖器距离较短或女性 AGD 的任何变化相关。PFOA 与较长的阴囊距离之间观察到的正关联是真实的，还是会对男性的生殖健康产生任何持久影响，尚不清楚，需要进一步调查。
