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在杂交一期姑息治疗左心发育不全综合征新生儿中,双侧肺带结扎术的麻醉。

Anesthesia for bilateral pulmonary banding as part of hybrid stage I approach palliating neonates with hypoplastic left heart syndrome.

机构信息

Paediatric Cardiac Anesthesiology Service, Pediatric Heart Centre, Department of Anaesthesiology Intensive Care Medicine, Pain Therapy, University Hospital Giessen and Marburg GmbH, Giessen, Germany.

Department of Pediatric and Congenital Heart Surgery, Pediatric Heart Centre, University Hospital Giessen and Marburg GmbH, Giessen, Germany.

出版信息

Paediatr Anaesth. 2020 Jun;30(6):691-697. doi: 10.1111/pan.13876. Epub 2020 Apr 30.

Abstract

BACKGROUND

Neonatal management of patients with hypoplastic left heart syndrome and complex remains a challenging task, whereby the "hybrid" palliation is often reserved for high-risk patients as a "rescue" procedure.

AIM

This study documents the anesthetic challenges and potential complications associated with the Giessen hybrid stage I approach.

METHODS

The Giessen hybrid stage I approach is focused on surgical bilateral pulmonary artery banding. Retrospective perioperative data were analyzed. Contrary to a stable group A, inotropic treatment before surgery for treatment of postnatal shock classified patients as unstable (Group B). Clinical outcomes considered were inhospital mortality, duration of postoperative mechanical ventilation, postoperative time at the intensive care unit, perioperative vasoactive medication requirements, and red blood cell transfusion.

RESULTS

From June 1998 to December 2015, 185 patients were allocated to Group A (n = 165) and Group B (n = 20). The inhospital mortality was 2.2% with no difference between the groups. There was also no difference in the postoperative time on mechanical ventilation and the time in the intensive care unit. Vasoactive medication was more often required in Group B (100%) compared to Group A (19%). In Group B, more red blood cells were transfused 6.0 ± 8.3 vs 2.0 ± 5.8 mL/kg in Group A (P < .05, 95% CI 0.0 - 2.6).

CONCLUSION

Considering a learning curve, anesthesia for surgical bilateral pulmonary artery banding palliating patients with hypoplastic left heart syndrome and complex can safely be performed, independent from the preoperative clinical status.

摘要

背景

新生儿患有左心发育不全综合征和复杂畸形的管理仍然是一项具有挑战性的任务,其中“杂交”姑息治疗通常作为“抢救”手术保留给高危患者。

目的

本研究记录了与吉森杂交一期手术相关的麻醉挑战和潜在并发症。

方法

吉森杂交一期手术侧重于双侧肺动脉环扎术。回顾性分析围手术期数据。与稳定的 A 组相反,为治疗新生儿休克而在手术前进行的正性肌力治疗将患者分为不稳定组(B 组)。考虑的临床结果包括院内死亡率、术后机械通气时间、术后重症监护病房时间、围手术期血管活性药物需求和红细胞输注。

结果

1998 年 6 月至 2015 年 12 月,185 例患者分为 A 组(n=165)和 B 组(n=20)。院内死亡率为 2.2%,两组之间无差异。机械通气时间和重症监护病房时间也无差异。B 组血管活性药物的需求更频繁(100%),而 A 组(19%)。B 组输注的红细胞更多 6.0±8.3 vs A 组 2.0±5.8 mL/kg(P<.05,95%CI 0.0-2.6)。

结论

考虑到学习曲线,为患有左心发育不全综合征和复杂畸形的患者进行双侧肺动脉环扎姑息治疗的麻醉可以安全进行,与术前临床状况无关。

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