Microbiology, Bioorganic and Macromolecular Chemistry, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), Bruxelles, 1050, Belgium.
Chem Commun (Camb). 2020 May 7;56(37):4970-4981. doi: 10.1039/d0cc00841a. Epub 2020 Apr 16.
Two decades ago, halogen bonding attracted considerable attention as a new type of non-covalent interaction and has now emerged as an important supramolecular tool for crystal engineering, demonstrating its ability to self-assemble low affinity entities. Specific features of halogen bonds have been subsequently harnessed in biological and material sciences to give rise to elegant functional systems with a wide range of applications. In this highlight, we focused on new concepts in polymer science, electrochemistry, electronic and sensing materials. Recent findings on the use of halogenated compounds for transmembrane transport are also discussed, together with a short summary of the current understanding of the nature of the halogen bond, in the light of modern computational tools and energy decomposition.
二十年前，卤键作为一种新型非共价相互作用引起了广泛关注，现已成为晶体工程的重要超分子工具，展示了其将低亲和力实体自组装的能力。卤键的特定性质随后被应用于生物和材料科学，产生了具有广泛应用的优雅功能系统。在这个亮点中，我们专注于聚合物科学、电化学、电子和传感材料的新概念。还讨论了卤代化合物在跨膜运输中的最新应用发现，以及根据现代计算工具和能量分解对卤键性质的当前理解的简短总结。
