Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27104, United States of America.
Wake Forest Baptist Medical Center, Department of Otolaryngology-Head and Neck Surgery, United States of America.
Am J Otolaryngol. 2020 Jul-Aug;41(4):102477. doi: 10.1016/j.amjoto.2020.102477. Epub 2020 Apr 6.
Postoperative hypocalcemia is a well-described outcome following thyroid and parathyroid surgery with symptoms ranging from clinically insignificant laboratory findings to tetany and seizures. The aims of this study were 1. To identify the characteristics and management patterns of postoperative hypocalcemia in head and neck endocrine surgery patients and 2. To compare outcomes between patients treated with empiric calcium and patients treated using a biochemically driven calcium replacement algorithm. Clinical electronic medical record (EMR) data was collected from patients who had undergone total thyroidectomy, completion thyroidectomy, and/or parathyroidectomy at Wake Forest Baptist Medical Center (WFBMC), a tertiary referral and academic institution. Between July 1, 2016, and June 30, 2017, 298 adult patients underwent surgery by a WFBMC Head & Neck (H&N) endocrine surgeon. Objective calcium and parathyroid hormone levels, postoperative supplementation with calcium and Vitamin D, 30-day physician access line (PAL) phone call utilization, emergency department (ED) encounters, and readmission rates were queried. The overall rate of hypocalcemia was 17.4%. No statistically significant difference in PAL utilization, ED visits, or readmissions was found between the empiric supplementation group and those whose supplementation was biochemically directed (PAL 5.0% vs. 5.0% [p = 0.983], ED visit 3.3% vs. 2.5% [p = 0.744], Readmission 1.7% vs. 0% [p = 0.276]). The overall postoperative rates of hypocalcemia and hypoparathyroidism following H&N endocrine surgery were consistent with the reported literature. Neither method of calcium supplementation was superior in reducing PAL utilization, ED encounters, or readmission.
术后低钙血症是甲状腺和甲状旁腺手术后的一种常见并发症,其症状从无临床意义的实验室发现到抽搐和癫痫发作不等。本研究的目的是:1. 确定头颈部内分泌手术患者术后低钙血症的特征和管理模式;2. 比较经验性补钙和基于生化指标补钙两种治疗方法的结局。本研究收集了 2016 年 7 月 1 日至 2017 年 6 月 30 日期间在维克森林浸信会医疗中心(WFBMC)接受全甲状腺切除术、补充性甲状腺切除术和/或甲状旁腺切除术的 298 例成年患者的临床电子病历(EMR)数据。WFBMC 头颈部(H&N)内分泌外科医生对这些患者进行了手术。检测了术后患者的血钙和甲状旁腺激素水平、补钙和维生素 D 补充情况、30 天医生访问线(PAL)电话使用情况、急诊(ED)就诊情况和再入院率。低钙血症的总发生率为 17.4%。在经验性补钙组和基于生化指标补钙组之间,PAL 使用率、ED 就诊率或再入院率无统计学差异(PAL 使用率为 5.0%比 5.0%[p=0.983],ED 就诊率为 3.3%比 2.5%[p=0.744],再入院率为 1.7%比 0%[p=0.276])。H&N 内分泌手术后低钙血症和甲状旁腺功能减退症的总体术后发生率与文献报道一致。两种补钙方法在降低 PAL 使用率、ED 就诊率或再入院率方面均无优势。