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甘草次酸对二氧化钛纳米颗粒诱导的大鼠肝毒性中[具体物质]和[具体物质]表达的影响 。 （注：原文中“and”前后的内容缺失，所以翻译可能不太完整准确，需补充完整原文信息才能更精准翻译。）

The effect of glycyrrhizin acid on and expression in hepatotoxicity induced by Titanium dioxide nanoparticles in rats.

作者信息

Orazizadeh Mahmoud, Khorsandi Layasadat, Mansouri Esrafil, Fakhredini Fereshtesadat

机构信息

Cell & Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

出版信息

Gastroenterol Hepatol Bed Bench. 2020 Spring;13(2):168-176.

PMID:32308939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7149808/
Abstract

AIM

This research studied the effects of glycyrrhizic acid (GA) on apoptosis induced with by titanium dioxide (NTiO2) in the liver of rats.

BACKGROUND

It is widely accepted that the contamination resulting from nanoparticles (NPs) is an emerging dangerous issue. Metal oxide nanoparticles have high environmental stability and cause toxicity in the food chain. Thus, the present study investigated the anti-apoptotic effects of glycyrrhizic acid (GA) on the hepatotoxicity generated by titanium dioxide (NTiO2) NPs in the liver tissue.

METHODS

Thirty-two male Wistar rats were randomly divided into four groups. NTiO2-treated rats were given 300 mg / kg of NTiO2 solution via gavage for 14 days; GA-treated were administered 100 mg/kg GA for 14 days; protection group was pre-treated with GA before NTiO2 administration for 7 days. Then, apoptotic index was evaluated through immunolocalization of Bax and Bcl-2 and TUNEL assay.

RESULTS

we found that HSCORE of Bax expression and apoptotic index experienced a significant increase with NTiO2 (P <0.001), while Bcl-2 expression significantly diminished in NTiO2-treated rats (P <0.001). The results revealed that the increased Bax expression and apoptotic index were reversed by GA and enhanced the activities of Bcl2.

CONCLUSION

The results revealed that GA effectively attenuated apoptosis against NTiO2 in rats.

摘要

目的

本研究探讨甘草酸（GA）对二氧化钛（NTiO2）诱导的大鼠肝脏细胞凋亡的影响。

背景

纳米颗粒（NPs）造成的污染是一个新出现的危险问题，这一点已得到广泛认可。金属氧化物纳米颗粒具有很高的环境稳定性，并会在食物链中产生毒性。因此，本研究调查了甘草酸（GA）对肝脏组织中二氧化钛（NTiO2）纳米颗粒产生的肝毒性的抗凋亡作用。

方法

将32只雄性Wistar大鼠随机分为四组。给NTiO2处理组大鼠经口灌胃给予300 mg/kg的NTiO2溶液，持续14天；GA处理组给予100 mg/kg GA，持续14天；保护组在给予NTiO2前用GA预处理7天。然后，通过Bax和Bcl-2的免疫定位及TUNEL检测评估凋亡指数。

结果

我们发现，NTiO2处理后，Bax表达的HSCORE和凋亡指数显著增加（P <0.001），而NTiO2处理组大鼠的Bcl-2表达显著降低（P <0.001）。结果显示，GA可逆转Bax表达增加和凋亡指数升高，并增强Bcl2的活性。

结论

结果表明，GA可有效减轻大鼠肝脏中NTiO2诱导的细胞凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/bcee7f76e79e/GHFBB-13-168-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/58851636fc99/GHFBB-13-168-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/cea44ba9eaba/GHFBB-13-168-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/848b0e214c13/GHFBB-13-168-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/ffc710180726/GHFBB-13-168-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/e8275fcca820/GHFBB-13-168-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/49c24da3cc1f/GHFBB-13-168-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/bcee7f76e79e/GHFBB-13-168-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/58851636fc99/GHFBB-13-168-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/1bc38b106980/GHFBB-13-168-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/cea44ba9eaba/GHFBB-13-168-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/848b0e214c13/GHFBB-13-168-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/ffc710180726/GHFBB-13-168-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/e8275fcca820/GHFBB-13-168-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/49c24da3cc1f/GHFBB-13-168-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed38/7149808/bcee7f76e79e/GHFBB-13-168-g008.jpg

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