过滤器收集的颗粒物化学和生物学指标比较的工作流程
Workflow for Comparison of Chemical and Biological Metrics of Filter Collected PM.
作者信息
Roper Courtney, Perez Allison, Barrett Damien, Hystad Perry, Massey Simonich Staci L, Tanguay Robyn L
机构信息
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331.
Department of Microbiology, Oregon State University, Corvallis, OR 97331.
出版信息
Atmos Environ (1994). 2020 Apr 1;226. doi: 10.1016/j.atmosenv.2020.117379. Epub 2020 Mar 5.
There is limited understanding of adverse health effect associations with chemical constituents of fine particulate matter (PM) as well as the underlying mechanisms. We outlined a workflow to assess metrics, beyond concentration, using household and personal PM filter samples collected in India as a proof of concept for future large-scale studies. Oxidative potential, chemical composition (polycyclic aromatic hydrocarbons and elements), and bioactivity (developmental exposures in zebrafish) were determined. Significant differences were observed in all metrics between personal and household PM samples. This work established methods to characterize multiple metrics of PM to ultimately support the identification of more health-relevant metrics than concentration.
目前，人们对细颗粒物（PM）化学成分与不良健康影响之间的关联及其潜在机制了解有限。我们概述了一种工作流程，以评估除浓度之外的指标，该流程采用在印度收集的家庭和个人PM过滤器样本作为未来大规模研究的概念验证。我们测定了氧化潜力、化学成分（多环芳烃和元素）以及生物活性（斑马鱼的发育暴露）。在个人和家庭PM样本的所有指标中均观察到显著差异。这项工作建立了表征PM多种指标的方法，以最终支持识别比浓度更具健康相关性的指标。
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