短期实验性糖尿病对脑血清素代谢的影响。
Effects of short term experimental diabetes on brain serotonin metabolism.
作者信息
Atienza G, Aldegunde M, Durán R, Veira J A
机构信息
Departamento de Fisiología, Facultad de Biología, Santiago de Compostela, Spain.
出版信息
Rev Esp Fisiol. 1988 Sep;44(3):279-82.
Serotonin metabolism was studied in several brain regions of control and Streptozotocin-treated male Wistar rats. After induction of diabetes, the animals were killed at 24 hours. Concentrations of brain tryptophan show a generalized increase in all brain regions, being only significant in medulla-pons. Serotonin levels do not change, while 5-HIAA concentrations, as well as the ratio 5-HIAA/5-HT, show significant increases in medulla-pons and mid-brain.
在对照和经链脲佐菌素处理的雄性Wistar大鼠的几个脑区中研究了血清素代谢。诱导糖尿病后，在24小时处死动物。脑色氨酸浓度在所有脑区均呈现普遍升高，仅在延髓-脑桥中显著。血清素水平未发生变化，而5-羟吲哚乙酸（5-HIAA）浓度以及5-HIAA/5-羟色胺（5-HT）比值在延髓-脑桥和中脑呈现显著升高。
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