Ruiz Moreno M, García Aguado J, Carreño García V, Alvarez Sala L, Rincón Víctor P, López-Linares del Prado M, Bas Pérez C
Servicio de Pediatría, Fundación Jiménez Díaz, Universidad Autónoma, Madrid.
An Esp Pediatr. 1988 Nov;29(5):357-62.
The aim of this study was to determine the prevalence due to hepatitis A, B and D viruses infection in children. A total of 286 children from Madrid area with ages ranging between 0 and 13 years were included. The sample was randomized with respect to the sex and age referring to the total population of Madrid. The anti-HAV was positive in 15.16% of cases, with an increasing lineal correlation with age. Any marker of HBV infection was found in 6.6% and HBsAg in 1.4%. There was an exponential correlation between the carrier state and the age, with a maximum at the first year and diminishing thereafter with age. The 21% of the cases with positive HBV-markers were HBsAg carriers. A predominant perinatal and intrafamiliar transmission of HBV was detected. Our results indicate a intermediate prevalence of HBV infection in Spain, suggesting the importance of HBsAg detection in pregnant women. None of the HBV-infected cases had anti-HD.
本研究的目的是确定儿童中甲型、乙型和丁型肝炎病毒感染的流行情况。共纳入了286名来自马德里地区、年龄在0至13岁之间的儿童。该样本在性别和年龄方面相对于马德里的总人口进行了随机抽样。15.16%的病例抗-HAV呈阳性,且与年龄呈线性正相关。6.6%的病例发现有任何乙型肝炎病毒感染标志物,1.4%的病例HBsAg呈阳性。携带状态与年龄之间存在指数相关性,在第一年最高,此后随年龄增长而下降。21%的乙型肝炎病毒标志物阳性病例为HBsAg携带者。检测到乙型肝炎病毒主要通过围产期和家庭内传播。我们的结果表明西班牙乙型肝炎病毒感染的流行率处于中等水平,提示对孕妇进行HBsAg检测的重要性。所有乙型肝炎病毒感染病例均未检测到抗-HD。