Subacute meningitis caused by Brucella: a diagnostic challenge.

A case of subacute meningitis caused by Brucella mellitensis is described. The meningitis was refractory to an antibiotic regime. Diagnosis was established by raised antibody titres to Brucella in serum and cerebrospinal fluid (CSF) and positive bone marrow and blood cultures. While treatment with tetracycline trimethoprim-sulfamethoxazole and streptomycin resulted in a dramatic clinical cure, the CSF findings returned only gradually to normal values over the ensuing 6 months.