Ray Max, McGee Michael, Collins Nicholas, Cooke Heather
Cardiovascular Department, John Hunter Hospital, Lookout Road, New Lambton Heights, Newcastle 2305, New South Wales, Australia.
University of Newcastle, Newcastle, New South Wales, Australia.
Eur Heart J Case Rep. 2020 Feb 20;4(2):1-5. doi: 10.1093/ehjcr/ytaa021. eCollection 2020 Apr.
Mycotic aneurysms of coronary vein grafts are rare and associated with high mortality. They are most commonly a result of surgical or percutaneous intervention, and present with complications including myocardial infarction (MI), infective endocarditis. A recent literature review identified 97 cases of mycotic coronary aneurysms in total.
A 49-year-old man with a history of coronary artery bypass grafting and septic arthrithis presented with chest pain and fevers and ST elevation on electrocardiogram. Urgent angiogram showed an aneurysmal saphenous vein graft from the PL branch to PDA-no acute intervention was performed due to concern about bacteraemia. Methicillin-sensitive was grown in urine and blood but no focus of infection was identified. Despite treatment with antibiotics and antiplatelets, the patient returned with evidence of expansion of the SVG aneurysm requiring surgical resection.
This case highlights the difficulty in treating acute coronary syndromes involving mycotic aneurysms. Multimodal imaging approaches are useful to identify suspected infection, but false negatives occur. Due to high risk of rupture or haemorrhage, there are limited options for urgent reperfusion in cases of MI with mycotic aneurysm, demonstrating the need for an individualized approach and close follow-up.
冠状动脉移植血管的霉菌性动脉瘤罕见且死亡率高。它们最常见于手术或经皮介入后,常伴有包括心肌梗死(MI)、感染性心内膜炎等并发症。最近的一篇文献综述共确定了97例霉菌性冠状动脉瘤病例。
一名49岁男性,有冠状动脉搭桥手术和脓毒性关节炎病史,出现胸痛、发热,心电图显示ST段抬高。紧急血管造影显示从PL分支到PDA的大隐静脉移植血管呈瘤样扩张——由于担心菌血症,未进行紧急干预。尿和血培养出对甲氧西林敏感的[细菌名称未给出],但未发现感染灶。尽管使用了抗生素和抗血小板药物治疗,患者复诊时显示SVG动脉瘤有扩大迹象,需要手术切除。
该病例凸显了治疗涉及霉菌性动脉瘤的急性冠状动脉综合征的困难。多模态成像方法有助于识别疑似感染,但会出现假阴性结果。由于破裂或出血风险高,霉菌性动脉瘤合并心肌梗死时紧急再灌注的选择有限,这表明需要个体化方法和密切随访。