Koshiishi I, Shibayama R, Morimoto Y, Imanari T
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
J Pharmacobiodyn. 1988 Nov;11(11):730-5. doi: 10.1248/bpb1978.11.730.
Metabolic pathways of cyanate in rats were studied by means of measurements of cyanate, carbamyl phosphate and S-carbamyl group. Approximately 30-50% of cyanate administered to rats (0.5 mmol/kg body weight) was found in buffered gastric contents, and was also detected as ammonia liberated by acid hydrolysis. However, the gastric excretion of cyanate was a temporary phenomenon just after cyanate administration. Biliary and urinary excretion of cyanate and acid-soluble S-carbamyl group are minor metabolic pathways.
通过测定氰酸盐、氨基甲酰磷酸和S-氨甲酰基研究了大鼠体内氰酸盐的代谢途径。给大鼠（0.5 mmol/kg体重）注射的氰酸盐中，约30-50%存在于缓冲后的胃内容物中，并且也能检测到经酸水解释放出的氨。然而，氰酸盐的胃排泄只是在给药后刚出现的一种暂时现象。氰酸盐和酸溶性S-氨甲酰基的胆汁和尿液排泄是次要的代谢途径。
