Department of Nursing Platform for Bone and Joint and Sports Medicine, The First Hospital of Jilin University, Changchun, China.
Department of Operation Room, The First Hospital of Jilin University, Changchun, China.
J Biomater Sci Polym Ed. 2020 Aug;31(12):1538-1551. doi: 10.1080/09205063.2020.1764163. Epub 2020 May 13.
The long circulation time and targeting drug delivery at tumor sites are still the main challenges of nanodrug delivery systems for antitumor activity. Herein, a cancer cell membrane-coated biomimetic nanodrug delivery system was fabricated. The paclitaxel (PTX)-loaded poly(lactic acid) (PLA) nanoparticles (PPNs) were used as the inner cores and 4T1 cancer cell membranes were coated on the surface of PPNs as the outer shells. The biomimetic platform was noted as CPPNs. The CPPNs exhibited proper sizes for the enhanced permeability and retention (EPR) effect and could maintain stability in a simulated physiological environment. The CPPNs exhibited a better antitumor effect than PPNs and free PTX . Moreover, due to the immune escape and homologous targeting abilities endowed by the cancer cell membrane coating, the CPPNs could efficiently accumulate and long-term exist at tumor sites. In the orthotopic 4T1 breast cancer mouse model, the CPPNs effectively inhibited the progression of tumor by increasing the apoptosis and necrosis areas within tumor tissues. In addition, the toxic side effects of PTX was also alleviated in the CPPNs group. As a result, CPPNs can be a promising biomimetic nanodrug delivery system for the enhanced and targeted therapy of breast cancer.
长循环时间和靶向肿瘤部位的药物递送仍然是抗肿瘤纳米药物递送系统的主要挑战。本文构建了一种细胞膜包覆的仿生纳米药物递送系统。载紫杉醇（PTX）的聚乳酸（PLA）纳米粒（PPNs）作为内芯，4T1 癌细胞膜作为外壳包覆在 PPNs 表面。该仿生平台被命名为 CPPNs。CPPNs 具有适当的尺寸，可增强渗透和保留（EPR）效应，并能在模拟生理环境中保持稳定。CPPNs 比 PPNs 和游离 PTX 具有更好的抗肿瘤效果。此外，由于细胞膜包覆赋予的免疫逃逸和同源靶向能力，CPPNs 能够有效地在肿瘤部位聚集并长期存在。在原位 4T1 乳腺癌小鼠模型中，CPPNs 通过增加肿瘤组织内的凋亡和坏死区域，有效抑制了肿瘤的进展。此外，CPPNs 组还减轻了 PTX 的毒性副作用。因此，CPPNs 有望成为增强和靶向治疗乳腺癌的仿生纳米药物递送系统。
