日本脐带血采集质量的相关因素
Factors Associated With Umbilical Cord Blood Collection Quality in Japan.
作者信息
Suzuki Shunji, Kimura Takafumi, Hara Sumiko, Ishimaru Fumihiko, Takanashi Minoko
机构信息
Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Tokyo, Japan.
Japanese Red Cross Kinki Block Blood Center, Osaka, Japan.
出版信息
J Hematol. 2020 Apr;9(1-2):9-12. doi: 10.14740/jh628. Epub 2020 Apr 23.
BACKGROUND
Umbilical cord blood (UCB) has become an established alternative source of hematopoietic stem cells with marrow and postmobilization peripheral blood. The presence of a large amount of clots may lead to the deterioration of cord blood quality. To improve UCB quality as a source of hematopoietic stem cells in Japan, we examined factors associated with UCB collection methods from the viewpoint of eliminating the presence of clots.
METHODS
In August 2019, we requested the directors of 74 certified facilities to provide information on UCB collection methods in Japan. A total of 46 (62.2%) of them responded with valid information on a total of 2,892 UCB collections. In this study, collected UCB without clots macroscopically was evaluated as a high-quality UCB.
RESULTS
The 2,891 UCB collections described during the study period were divided to those with (n = 760, 26.3%) and without clots (high quality; n = 2,131, 73.7%). Multivariate analysis revealed single puncture as a factor determining high-quality UCB collection (adjusted odds ratio (ORs): 1.80, 95% confidence interval (CI): 1.3 - 5.4, P = 0.01).
CONCLUSIONS
Single puncture is an independent effective factor determining high-quality manual UCB collection in Japan.
背景
脐带血（UCB）已成为继骨髓和动员后外周血之后一种既定的造血干细胞替代来源。大量凝块的存在可能导致脐带血质量下降。为了提高日本作为造血干细胞来源的脐带血质量，我们从消除凝块存在的角度研究了与脐带血采集方法相关的因素。
方法
2019年8月，我们要求74家认证机构的负责人提供日本脐带血采集方法的相关信息。其中共有46家机构（62.2%）回复了有关总共2892例脐带血采集的有效信息。在本研究中，宏观上无凝块的采集脐带血被评估为高质量脐带血。
结果
研究期间描述的2891例脐带血采集被分为有凝块的（n = 760，26.3%）和无凝块的（高质量；n = 2131，73.7%）。多变量分析显示单针穿刺是决定高质量脐带血采集的一个因素（调整后的优势比（ORs）：1.80，95%置信区间（CI）：1.3 - 5.4，P = 0.01）。
结论
在日本，单针穿刺是决定高质量手工采集脐带血的一个独立有效因素。
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