State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, PR China.
Dana Center for Preventive Ophthalmology at the Johns Hopkins Wilmer Eye Institute, Baltimore, MD, USA.
Eye (Lond). 2021 Feb;35(2):608-615. doi: 10.1038/s41433-020-0912-2. Epub 2020 May 4.
To evaluate the long-term outcome of patients with iridocorneal endothelial (ICE) syndrome who underwent Ahmed glaucoma valve implantation surgery for uncontrolled glaucoma.
Eighteen patients who suffered from unilateral ICE syndrome with uncontrolled glaucoma and subsequently underwent Ahmed aqueous shunt surgery at Zhongshan Ophthalmic Center between January 2008 and December 2016 were reviewed. Outcome measures included intraocular pressure (IOP), the use of glaucoma medications, visual acuity, further surgical interventions, and surgical complications.
The mean IOP was reduced from 34.8 ± 10.6 mmHg on 3.6 ± 0.5 medications to 17.4 ± 4.9 mmHg (t = 6.791, P = 0.000) on 1.6 ± 1.1 medications (Z = -3.545, P = 0.000) at the last follow-up (42.0 ± 19.3 months). Five eyes (27.8%) achieved complete success, nine (50.0%) achieved qualified success, and the remaining four (22.2%) were considered failures. Survival was 94.4% at 1 year, 88.1% at 2 years, and 73.5% at 3 years. Four cases displayed a flat anterior chamber and were treated with a single anterior chamber reformation surgery with no recurrence. No other complications related to the glaucoma drainage implants occurred in this series.
Ahmed glaucoma valve implantation appears to be a safe and effective method for treating glaucoma secondary to ICE syndrome. Postoperative shallow anterior chamber and hypotony may occur but responds well to the treatment. Early consideration may be given to aqueous shunt surgery in patients with glaucoma secondary to ICE syndrome when trabeculectomy fails.
评估因不受控制的青光眼而行 Ahmed 青光眼引流阀植入术的虹膜角膜内皮(ICE)综合征患者的长期疗效。
回顾 2008 年 1 月至 2016 年 12 月期间,中山大学中山眼科中心收治的 18 例单侧 ICE 综合征伴不受控制的青光眼患者,均行 Ahmed 房水引流阀手术。观察指标包括眼压(IOP)、青光眼药物使用、视力、进一步手术干预及手术并发症。
平均眼压从术前的 34.8±10.6mmHg 和使用 3.6±0.5 种降眼压药物降至术后的 17.4±4.9mmHg 和 1.6±1.1 种降眼压药物(t=6.791,P=0.000)。末次随访(42.0±19.3 个月)时,5 只眼(27.8%)达完全成功,9 只眼(50.0%)达基本成功,4 只眼(22.2%)为失败。1 年、2 年、3 年的累积存活率分别为 94.4%、88.1%和 73.5%。4 只眼发生浅前房,行单次前房重建术,未复发。本系列中未发生与青光眼引流植入物相关的其他并发症。
Ahmed 青光眼引流阀植入术治疗 ICE 综合征相关性青光眼安全有效。术后可能出现浅前房和低眼压,但对治疗反应良好。当小梁切除术失败时,对于 ICE 综合征相关性青光眼患者,可早期考虑房水引流手术。