Lee Tae Young, Lee Junhee, Lee Hyun Ju, Lee Yunna, Rhee Sang Jin, Park Dong Yeon, Paek Myung Jae, Kim Eun Young, Kim Euitae, Roh Sungwon, Jung Hee Yeon, Kim Minah, Kim Se Hyun, Han Dohyun, Ahn Yong Min, Ha Kyooseob, Kwon Jun Soo
Department of Neuropsychiatry, Pusan National University Yangsan Hospital, Yangsan, South Korea.
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Front Psychiatry. 2020 Apr 21;11:340. doi: 10.3389/fpsyt.2020.00340. eCollection 2020.
The Seoul Pluripotent Risk for Mental Illness (SPRIM) study was designed to identify predictors leading to mental illness in help-seeking individuals by securing sufficient statistical power through transdiagnostic approaches. The SPRIM study aims to examine the clinical characteristics of high-risk individuals for mental illness and to identify proteomic biomarkers that can predict the onset of mental illness.
This paper describes the study protocol of the SPRIM study. We aim to recruit 150 participants who meet the criteria for high risk for major mental illness, 150 patients with major psychiatric disorders (schizophrenia, bipolar disorder, and major depressive disorder), and 50 matched healthy control subjects for 2 years. Clinical evaluations, self-report measures, and proteomic analyses will be implemented. The assessment points are at baseline, 6, 12, 18, and 24 months.
In the present study, we introduced the study protocol of the SPRIM study, which is the first prospective cohort study of transdiagnostic high-risk concepts using proteomic biomarkers. This study has a paradigm that encompasses various diseases without aiming at predicting and preventing the development of a specific mental illness in help-seeking individuals. The transdiagnostic high-risk concept could be extended to provide a perspective for people with various psychopathological tendencies below a threshold, such that they do not meet the existing diagnostic criteria of mental illnesses, to determine what may lead them to a specific disease and help identify appropriate preventative interventions.
首尔精神疾病多能风险（SPRIM）研究旨在通过跨诊断方法确保足够的统计效力，从而识别寻求帮助的个体中导致精神疾病的预测因素。SPRIM研究旨在检查精神疾病高危个体的临床特征，并识别可预测精神疾病发作的蛋白质组学生物标志物。
本文描述了SPRIM研究的研究方案。我们的目标是在2年内招募150名符合重度精神疾病高危标准的参与者、150名患有重度精神障碍（精神分裂症、双相情感障碍和重度抑郁症）的患者以及50名匹配的健康对照者。将实施临床评估、自我报告测量和蛋白质组学分析。评估时间点为基线、6个月、12个月、18个月和24个月。
在本研究中，我们介绍了SPRIM研究的研究方案，这是第一项使用蛋白质组学生物标志物进行跨诊断高危概念的前瞻性队列研究。本研究具有一种范式，涵盖各种疾病，而不是旨在预测和预防寻求帮助的个体中特定精神疾病的发展。跨诊断高危概念可以扩展，为低于阈值的具有各种精神病理学倾向、不符合现有精神疾病诊断标准的人群提供一个视角，以确定可能导致他们患上特定疾病的因素，并有助于确定适当的预防干预措施。
