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在巴门达地区医院就诊的成年疟疾患者中血液学参数的评估

Assessment of Hematological Parameters in Malaria, among Adult Patients Attending the Bamenda Regional Hospital.

作者信息

Omarine Nlinwe Nfor, Nange Tang Bertilla

机构信息

The University of Bamenda, Faculty of Health Sciences, Department of Medical Laboratory Science, PO Box 39 Bambili, Bamenda, Cameroon.

出版信息

Anemia. 2020 Apr 21;2020:3814513. doi: 10.1155/2020/3814513. eCollection 2020.

Abstract

Malaria, which is responsible for a substantial amount of deaths in endemic countries, has been shown to have both direct and indirect effects on the hematological parameters. Notwithstanding, some hematological parameters among populations living in malaria endemic regions have not been described consistently, as a standard for measuring malaria burden. Based on the above fact, this study was designed to assess some hematological changes and their diagnostic values in malaria infected patients. A total of 160 malaria positive adult patients, together with 81 healthy control adults were recruited for the study. For the malaria positive group, the female to male ratio was 1.38 : 1. Specifically, 74.38%, 10.00%, and 15.62% of those in the malaria positive group had mild, moderate, and severe parasitaemia, respectively. Leukemia, anemia, and thrombocytopenia were found to be significantly associated with malaria and were all estimated to be specific for the diagnosis of malaria. Anemia was, however, estimated to be both sensitive and specific for malaria diagnosis. Therefore, anemia offers the most diagnostic value in the malaria infected patients of this study.

摘要

疟疾在流行国家导致大量死亡,已被证明对血液学参数有直接和间接影响。尽管如此,生活在疟疾流行地区人群的一些血液学参数尚未得到一致描述,作为衡量疟疾负担的标准。基于上述事实,本研究旨在评估疟疾感染患者的一些血液学变化及其诊断价值。本研究共招募了160名疟疾阳性成年患者以及81名健康对照成年人。在疟疾阳性组中,女性与男性的比例为1.38∶1。具体而言,疟疾阳性组中分别有74.38%、10.00%和15.62%的患者患有轻度、中度和重度寄生虫血症。发现白血病、贫血和血小板减少症与疟疾显著相关,并且据估计它们都对疟疾诊断具有特异性。然而,贫血被估计对疟疾诊断既敏感又具有特异性。因此,贫血在本研究的疟疾感染患者中具有最大的诊断价值。

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