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随访期间细胞学恶化和病变增大是宫颈管小叶状腺增生恶变的有用指标：一例报告

Worsening cytology and lesion enlargement are useful indicators for malignant transformation of lobular endocervical glandular hyperplasia during follow-up: A case report.

作者信息

Kobara Hisanori, Miyamoto Tsutomu, Otsuki Toshiaki, Ohya Ayumi, Shiozawa Tanri

机构信息

Department of Obstetrics and Gynecology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.

Department of Laboratory Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.

出版信息

Gynecol Oncol Rep. 2020 Apr 11;32:100571. doi: 10.1016/j.gore.2020.100571. eCollection 2020 May.

DOI:10.1016/j.gore.2020.100571
PMID:32373692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7191578/
Abstract

•We report a case of MDA arising from clinical LEGH during 5 years of follow-up.•The first sign suggesting MDA was cellular atypia in endocervical cytology, and was followed by an increase in tumor size.•MDA lesion lacked in stromal reaction and MRI failed to detected MDA.•Worsening cytology and lesion enlargement are important signs for malignant change of LEGH during follow-up.

摘要

•我们报告了1例在5年随访期间由临床诊断的LEGH发展而来的MDA病例。

•提示MDA的首个迹象是宫颈细胞学检查中的细胞异型性，随后肿瘤大小增加。

•MDA病变缺乏间质反应，MRI未能检测到MDA。

•随访期间细胞学恶化和病变增大是LEGH恶变的重要征象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72c0/7191578/ab6bbb476e5c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72c0/7191578/3d6bc468bdd0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72c0/7191578/66b401325f28/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72c0/7191578/ab6bbb476e5c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72c0/7191578/3d6bc468bdd0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72c0/7191578/66b401325f28/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72c0/7191578/ab6bbb476e5c/gr3.jpg

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本文引用的文献

1
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J Obstet Gynaecol Res. 2016 Nov;42(11):1588-1598. doi: 10.1111/jog.13083. Epub 2016 Oct 8.
2
Case of minimal deviation adenocarcinoma: possible clinical link to lobular endocervical glandular hyperplasia as its origin.微小偏离性腺癌病例：可能与小叶状宫颈内膜腺体增生作为其起源存在临床关联。
J Obstet Gynaecol Res. 2015 Mar;41(3):483-7. doi: 10.1111/jog.12538. Epub 2014 Sep 26.
3
Clonality analysis suggests that STK11 gene mutations are involved in progression of lobular endocervical glandular hyperplasia (LEGH) to minimal deviation adenocarcinoma (MDA).
宫腔镜活检在疑似宫颈小叶状腺性增生病例中的诊断效用及与宫颈锥切术的比较
Healthcare (Basel). 2023 Jun 1;11(11):1619. doi: 10.3390/healthcare11111619.
4
Biology and management of lobular endocervical glandular hyperplasia.小叶宫颈腺性增生的生物学与处理。
J Obstet Gynaecol Res. 2022 Dec;48(12):3056-3067. doi: 10.1111/jog.15441. Epub 2022 Sep 30.
5
Limited frequency of malignant change in lobular endocervical glandular hyperplasia.局限性小叶型宫颈内膜腺上皮增生恶变率低。
Int J Gynecol Cancer. 2020 Oct;30(10):1480-1487. doi: 10.1136/ijgc-2020-001612. Epub 2020 Sep 3.
克隆性分析表明 STK11 基因突变参与了小叶宫颈腺上皮增生（LEGH）向微偏腺癌（MDA）的进展。
Virchows Arch. 2013 Jun;462(6):645-51. doi: 10.1007/s00428-013-1417-1. Epub 2013 May 4.
4
Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings.术前鉴别诊断宫颈微小偏离性腺癌与宫颈管内柱状腺上皮增生：一项多中心临床病理与磁共振成像研究。
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Correlation between MRI and histopathologic findings in stage I cervical carcinomas: influence of stromal desmoplastic reaction.I期宫颈癌MRI与组织病理学结果的相关性：间质促纤维增生反应的影响
Int J Gynecol Cancer. 2006 Mar-Apr;16(2):610-4. doi: 10.1111/j.1525-1438.2006.00383.x.
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Cancer Cytopathol. 1999 Oct 25;87(5):245-53. doi: 10.1002/(sici)1097-0142(19991025)87:5<245::aid-cncr2>3.0.co;2-0.
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