Mo Hyejin, Ko Hyunmin, Chung Chris Tae Young, Kim Hyo Kee, Han Ahram, Min Sangil, Ha Jongwon
Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Transplantation Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Pediatr Transplant. 2021 Mar;25(2):e13719. doi: 10.1111/petr.13719. Epub 2020 May 6.
With small kidneys, EBKTs could provide sufficient renal mass but could lead to inefficient use of resources, while SKTs could result in insufficient function due to small renal mass. We aimed to compare the outcomes of EBKT and SKT from small donors weighing ≤15 kg to pediatric recipients. We retrospectively reviewed all pediatric patients who met the inclusion criteria between January 1, 1984, and April 30, 2019, at a single institution. Of a total of 23 patients, 12 received EBKT and 11 received SKT. The median age of donors, weight of donors, and weight of recipients were comparable between the two groups. The median age of recipients and median weight of allografts were greater in the EBKT group than in the SKT group. The median follow-up was 53.9 months. There was no significant difference in eGFR, protein creatinine ratios at 1-year follow-up, and overall graft survival. The size of the kidney increased by approximately 13%-43% in the EBKT group and 40%-60% in the SKT group. This study demonstrated that kidneys from small donors weighing 5-15 kg could be split in pediatric recipients without compromising the outcome.
对于小肾脏，扩大标准供肾（EBKT）可提供足够的肾实质，但可能导致资源利用效率低下，而标准供肾（SKT）可能因肾实质小而导致功能不足。我们旨在比较体重≤15千克的小供体的EBKT和SKT移植给儿科受者的结果。我们回顾性分析了1984年1月1日至2019年4月30日期间在单一机构符合纳入标准的所有儿科患者。在总共23例患者中，12例接受了EBKT，11例接受了SKT。两组之间供体的中位年龄、供体体重和受者体重具有可比性。EBKT组受者的中位年龄和同种异体移植物的中位重量高于SKT组。中位随访时间为53.9个月。在1年随访时的估算肾小球滤过率（eGFR）、蛋白肌酐比值和总体移植物存活率方面没有显著差异。EBKT组肾脏大小增加了约13%-43%，SKT组增加了40%-60%。这项研究表明，体重5-15千克的小供体的肾脏可以移植给儿科受者，而不影响结果。
