分枝杆菌-宿主相互作用中的甲基化及其对新型控制措施的意义。
Methylation in Mycobacterium-host interaction and implications for novel control measures.
机构信息
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400715, PR China; Department of biotechnology, Faculty of Science and Technology, Omdurman Islamic University, Omdurman, Khartoum, Sudan.
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-Environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400715, PR China; Department of Botany and Microbiology, Faculty of Science, Al-Azhar University Assuit branch, Egypt.
出版信息
Infect Genet Evol. 2020 Sep;83:104350. doi: 10.1016/j.meegid.2020.104350. Epub 2020 May 4.
Methylation epigenetically regulates many pivotal biological processes. Mycobacterium tuberculosis, the pathogen of tuberculosis, can modulate host methylome. The methylated genes, sites, signaling pathway, chromatin remodeling, especially the immune related genes such as cytokines and chemokines, drug resistance and vaccines efficacy relevant genes were summarized in this paper. The results showed that methylation plays important roles in immune evasion, pathogenesis, persistence, disease progression, active, drug responder and non-responder. This will inform better practice for the development of new drugs and vaccines to eradicate tuberculosis.
甲基化通过表观遗传调控许多关键的生物学过程。结核分枝杆菌是结核病的病原体，能够调节宿主的甲基组。本文总结了结核分枝杆菌甲基化的基因、位点、信号通路、染色质重塑等，特别是与细胞因子和趋化因子等免疫相关的基因、耐药性和疫苗效果相关的基因。结果表明，甲基化在免疫逃避、发病机制、持续存在、疾病进展、活动性、药物反应和无反应中起着重要作用。这将为开发新的药物和疫苗以根除结核病提供更好的实践依据。
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