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预防性电针可能通过抑制GSK3/mTOR信号通路改善D-半乳糖诱导的阿尔茨海默病样病理和记忆缺陷。

Preventive Electroacupuncture Ameliorates D-Galactose-Induced Alzheimer's Disease-Like Pathology and Memory Deficits Probably via Inhibition of GSK3/mTOR Signaling Pathway.

作者信息

Yu Chao-Chao, Wang Jia, Ye Si-Si, Gao Shan, Li Jia, Wang Li, Jiang Tao, Wang Xue-Song, Li Bo-Cun, Shu Qing, Lu Wei, Du Yan-Jun, Kong Li-Hong

机构信息

College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China.

Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Hubei University of Chinese Medicine, Wuhan, Hubei, China.

出版信息

Evid Based Complement Alternat Med. 2020 Apr 23;2020:1428752. doi: 10.1155/2020/1428752. eCollection 2020.

DOI:10.1155/2020/1428752
PMID:32382276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7195631/
Abstract

Acupuncture has been practiced to treat neuropsychiatric disorders for a thousand years in China. Prevention of disease by acupuncture and moxibustion treatment, guided by the theory of Chinese acupuncture, gradually draws growing attention nowadays and has been investigated in the role of the prevention and treatment of mental disorders such as AD. Despite its well-documented efficacy, its biological action remains greatly invalidated. Here, we sought to observe whether preventive electroacupuncture during the aging process could alleviate learning and memory deficits in D-galactose-induced aged rats. We found that preventive electroacupuncture at GV20-BL23 acupoints during aging attenuated the hippocampal loss of dendritic spines, ameliorated neuronal microtubule injuries, and increased the expressions of postsynaptic PSD95 and presynaptic SYN, two important synapse-associated proteins involved in synaptic plasticity. Furthermore, we observed an inhibition of GSK3/mTOR pathway activity accompanied by a decrease in tau phosphorylation level and prompted autophagy activity induced by preventive electroacupuncture. Our results suggested that preventive electroacupuncture can prevent and alleviate memory deficits and ameliorate synapse and neuronal microtubule damage in aging rats, which was probably via the inhibition of GSK3/mTOR signaling pathway. It may provide new insights for the identification of prevention strategies of AD.

摘要

在中国，针刺疗法治疗神经精神疾病已有千年历史。以中医针灸理论为指导，通过针刺和艾灸治疗预防疾病，如今逐渐受到越来越多的关注，并已在预防和治疗如阿尔茨海默病（AD）等精神障碍方面展开研究。尽管其疗效有充分记录，但其生物学作用仍大多未得到证实。在此，我们试图观察衰老过程中的预防性电针是否能减轻D - 半乳糖诱导的衰老大鼠的学习和记忆缺陷。我们发现，衰老过程中在百会（GV20） - 膀胱经23穴（BL23）进行预防性电针可减轻海马树突棘的丢失，改善神经元微管损伤，并增加突触后PSD95和突触前SYN这两种参与突触可塑性的重要突触相关蛋白的表达。此外，我们观察到预防性电针抑制了GSK3/mTOR信号通路的活性，同时伴随着tau蛋白磷酸化水平的降低以及自噬活性的增强。我们的结果表明，预防性电针可预防和减轻衰老大鼠的记忆缺陷，并改善突触和神经元微管损伤，这可能是通过抑制GSK3/mTOR信号通路实现的。它可能为确定AD的预防策略提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/34a8aefec288/ECAM2020-1428752.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/0cd21bc8820b/ECAM2020-1428752.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/f23238a7d254/ECAM2020-1428752.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/a47898c73260/ECAM2020-1428752.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/0c7d3421c1f2/ECAM2020-1428752.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/84162e9e3964/ECAM2020-1428752.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/34a8aefec288/ECAM2020-1428752.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/0cd21bc8820b/ECAM2020-1428752.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/f23238a7d254/ECAM2020-1428752.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/a47898c73260/ECAM2020-1428752.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/0c7d3421c1f2/ECAM2020-1428752.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/84162e9e3964/ECAM2020-1428752.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad22/7195631/34a8aefec288/ECAM2020-1428752.006.jpg

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