Xiang Qingyong, Jiang Chonggui, Wen Jiangzhi, Deng Bin
Department of Neurosurgery, Aba Tibetan and Qiang Autonomous Prefecture People's Hospital, barkam, China.
Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 610072, China.
Childs Nerv Syst. 2021 Jan;37(1):305-309. doi: 10.1007/s00381-020-04623-5. Epub 2020 May 7.
Pediatric brain abscesses usually occur as a consequence of predisposing conditions, such as ENT (ear, nose, and throat) infection and physical damage. But there are still a number of cryptogenic infection cases.
We present an unusual cryptogenic infection case of multiple and multiloculated brain abscess in an infant, which was in the absence of ENT infection, meningitis, trauma, prior surgery, cyanotic heart disease, or immune defect. The child has no specific symptoms but keeping apathic and days of diarrhea. Deduced from clinical presentation and this case's DWI-MRI features, the onset of infection is hematogenous route, and the diarrhea could be the possible inducement. The child was successfully treated by surgical excision of big lesions and an 8-week total course of intravenous antibiotics. At the end of the 1-year follow-up period, the infant is well at both of physical and mental health.
The interest of this case is the silent clinical presentation and the possibly rare precipitating factor. To a certain extent, the variation trend of blood C-reactive protein level could predict the clinical effect of antibiotics in brain abscess case.
小儿脑脓肿通常由诸如耳鼻喉(耳、鼻、喉)感染和身体损伤等易感因素引起。但仍有一些隐源性感染病例。
我们报告一例婴儿罕见的隐源性多发性多房性脑脓肿感染病例,该病例不存在耳鼻喉感染、脑膜炎、创伤、既往手术、先天性心脏病或免疫缺陷。患儿无特异性症状,仅表现为冷漠和腹泻数天。根据临床表现及该病例的弥散加权成像-磁共振成像(DWI-MRI)特征推断,感染途径为血行播散,腹泻可能是诱因。通过手术切除大的病灶并静脉注射抗生素治疗8周,患儿成功治愈。在1年随访期结束时,婴儿身心健康状况良好。
该病例的关注点在于其隐匿的临床表现和可能罕见的诱发因素。在一定程度上,血C反应蛋白水平的变化趋势可预测脑脓肿病例中抗生素的临床疗效。